2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. DSG Crosslinker

DSG Crosslinker  (Synonyms: Disuccinimidyl glutarate)

Cat. No.: HY-114697 Purity: 98.13%
COA Handling Instructions

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DSG Crosslinker is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

DSG Crosslinker Chemical Structure

DSG Crosslinker Chemical Structure

CAS No. : 79642-50-5

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50 mg USD 110 In-stock
100 mg USD 160 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of DSG Crosslinker:

DSG Crosslinker Related Antibodies

Top Publications Citing Use of Products

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  • Purity & Documentation

  • References

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Description

DSG Crosslinker is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target

Cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DSG Crosslinker Related Antibodies
Molecular Weight

326.26

Formula

C13H14N2O8
CAS No.
Appearance

Solid

Color

Off-white to gray

SMILES

O=C(CCCC(ON1C(CCC1=O)=O)=O)ON2C(CCC2=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (306.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0650 mL 15.3252 mL 30.6504 mL
5 mM 0.6130 mL 3.0650 mL 6.1301 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.13%

COA (249 KB) HNMR (239 KB) LCMS (260 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0650 mL 15.3252 mL 30.6504 mL 76.6260 mL
5 mM 0.6130 mL 3.0650 mL 6.1301 mL 15.3252 mL
10 mM 0.3065 mL 1.5325 mL 3.0650 mL 7.6626 mL
15 mM 0.2043 mL 1.0217 mL 2.0434 mL 5.1084 mL
20 mM 0.1533 mL 0.7663 mL 1.5325 mL 3.8313 mL
25 mM 0.1226 mL 0.6130 mL 1.2260 mL 3.0650 mL
30 mM 0.1022 mL 0.5108 mL 1.0217 mL 2.5542 mL
40 mM 0.0766 mL 0.3831 mL 0.7663 mL 1.9157 mL
50 mM 0.0613 mL 0.3065 mL 0.6130 mL 1.5325 mL
60 mM 0.0511 mL 0.2554 mL 0.5108 mL 1.2771 mL
80 mM 0.0383 mL 0.1916 mL 0.3831 mL 0.9578 mL
100 mM 0.0307 mL 0.1533 mL 0.3065 mL 0.7663 mL
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DSG Crosslinker Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DSG Crosslinker79642-50-5Disuccinimidyl glutarateADC LinkerAntibody-drug conjugates linkercleavableADClinkerInhibitorinhibitorinhibit

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