2. Cell Cycle/DNA Damage Neuronal Signaling
  3. CDK Amyloid-β
  4. DSS30

DSS30 is a P25/CDK5 inhibitor that reduces β-amyloid (Aβ) secretion by inhibiting amyloid precursor protein lyase 1 (BACEl) phosphorylation. DSS30 can be used in the study of neurodegenerative diseases such as Alzheimer's disease.

For research use only. We do not sell to patients.

DSS30 Chemical Structure

DSS30 Chemical Structure

CAS No. : 883027-32-5

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DSS30 Related Antibodies

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Description

DSS30 is a P25/CDK5 inhibitor that reduces β-amyloid (Aβ) secretion by inhibiting amyloid precursor protein lyase 1 (BACEl) phosphorylation. DSS30 can be used in the study of neurodegenerative diseases such as Alzheimer's disease[1].

In Vitro

DSS30 (50 μM, 2 hours) inhibits the activity of the P25/CDK5 complex by up to 50% and the phosphorylation of BACE1 or Tau[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DSS30 Related Antibodies

Western Blot Analysis[1]

Cell Line: Expressed P25 PC12tet-off cell lines
Concentration: 50 μM
Incubation Time: 8 hours
Result: Inhibited BACE1 phosphorylation by 12%.
Molecular Weight

367.87

Formula

C16H14ClNO3S2
CAS No.
SMILES

CC1=C(S(NC2=CC=CC=C2OC)(=O)=O)SC(C=C3)=C1C=C3Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DSS30 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DSS30883027-32-5DSS 30DSS-30CDKAmyloid-βCyclin dependent kinaseβ-amyloid peptideAβAbetaP25CDK5β-amyloidBACElAlzheimer's diseaseADInhibitorinhibitorinhibit

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