2. GPCR/G Protein
  3. Angiotensin Receptor
  4. DuP-532

DuP-532 is an angiotensin type 1 receptor antagonist with potential activity in the suppression of hypertension and heart failure. DuP-532 can react with a range of aryl and heteroaryl halides to form perfluoroalkyl(hetero)arenes in moderate to high yields. Computational studies of DuP-532 suggest that coordination of a second phenyl ring ligand may lower the energy barrier for decarboxylation of perfluorocarboxylates, thereby promoting the perfluoroalkylation reaction.

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DuP-532 Chemical Structure

DuP-532 Chemical Structure

CAS No. : 124750-95-4

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DuP-532 Related Antibodies

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Description

DuP-532 is an angiotensin type 1 receptor antagonist with potential activity in the suppression of hypertension and heart failure. DuP-532 can react with a range of aryl and heteroaryl halides to form perfluoroalkyl(hetero)arenes in moderate to high yields. Computational studies of DuP-532 suggest that coordination of a second phenyl ring ligand may lower the energy barrier for decarboxylation of perfluorocarboxylates, thereby promoting the perfluoroalkylation reaction[1].

Molecular Weight

506.43

Formula

C23H19F5N6O2
CAS No.
SMILES

O=C(C1=C(C(F)(C(F)(F)F)F)N=C(CCC)N1CC2=CC=C(C3=C(C4=NN=NN4)C=CC=C3)C=C2)O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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DuP-532 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DuP-532124750-95-4DuP532DuP 532Angiotensin ReceptorInhibitorinhibitorinhibit

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