2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. DuP 747 hydrochloride

DuP 747 hydrochloride is an analgesic with selective kappa-opioid receptor agonist activity. DuP 747 showed less spiradoline-appropriate selection when administered SC, but showed a partial generalized response to spiradoline when administered IP or PO. The 5-hydroxy-desmethoxy metabolite of DuP 747 induced selection of the saline-appropriate lever only. The effects of DuP 747 suggest that its metabolites may play a major role in the similar responses to spiradoline after IP and PO administration.

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DuP 747 hydrochloride Chemical Structure

DuP 747 hydrochloride Chemical Structure

CAS No. : 115904-74-0

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DuP 747 hydrochloride Related Antibodies

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Description

DuP 747 hydrochloride is an analgesic with selective kappa-opioid receptor agonist activity. DuP 747 showed less spiradoline-appropriate selection when administered SC, but showed a partial generalized response to spiradoline when administered IP or PO. The 5-hydroxy-desmethoxy metabolite of DuP 747 induced selection of the saline-appropriate lever only. The effects of DuP 747 suggest that its metabolites may play a major role in the similar responses to spiradoline after IP and PO administration[1].

Molecular Weight

483.86

Formula

C24H29Cl3N2O2
CAS No.
SMILES

ClC(C=C1CC(N([C@H]2C3=CC=CC(OC)=C3CC[C@@H]2N4CCCC4)C)=O)=C(C=C1)Cl.Cl
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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DuP 747 hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DuP 747115904-74-0DuP747DuP-747Opioid ReceptorInhibitorinhibitorinhibit

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