2. Metabolic Enzyme/Protease
  3. Oxidative Phosphorylation Mitochondrial Metabolism
  4. DX2-201

DX2-201 is a potent and selective oxidative phosphorylation (OXPHOS) complex I inhibitor with an IC50 of 312 nM. DX2-201 has anticancer effects.

For research use only. We do not sell to patients.

DX2-201 Chemical Structure

DX2-201 Chemical Structure

CAS No. : 2749554-00-3

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DX2-201 Related Antibodies

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Description

DX2-201 is a potent and selective oxidative phosphorylation (OXPHOS) complex I inhibitor with an IC50 of 312 nM. DX2-201 has anticancer effects[1].

IC50 & Target

IC50: 312 nM (OXPHOS complex I)[1]
In Vitro

DX2-201 (cmpound 2) potently inhibits the mitochondrial function by depleting ATP production in MIA PaCa-2 cells when glucose is replaced by galactose in the medium, a condition that forces mammalian cells to rely on OXPHOS[1].
DX2-201 depletes ATP production with an IC50 value of 118.5 nM in the galactose-containing medium[1].
DX2-201 significantly inhibits OXPHOS complex I as determined by its inhibition of oxidation of NADH to NAD+ in the NAD/NADH assay (IC50 = 312 nM)[1].
DX2-201 inhibits MIA PaCa-2 and BxPC-3 cells growth with IC50 values of 0.4 μM and 0.6 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DX2-201 Related Antibodies
Molecular Weight

432.55

Formula

C18H28N2O6S2
CAS No.
SMILES

O=S(N1C[C@@H](CCC1)C(OCC)=O)(C2=CC=C(C=C2)S(N(CC)CC)(=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DX2-201 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DX2-2012749554-00-3Oxidative PhosphorylationMitochondrial MetabolismOXPHOS complex I inhibitoranticancer effectsmitochondrial functionATP productionInhibitorinhibitorinhibit

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