DXR-IN-2 

DXR-IN-2 is a 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) inhibitor and an antimalarial agent (IC₅₀: 0.1062 μM for Plasmodium falciparum DXR and 0.369 μM for Plasmodium falciparum). DXR-IN-2 inhibits Plasmodium falciparum growth by suppressing the methyl erythritol phosphate (MEP) pathway via DXR^[1].

DXR-IN-2 (Compound 11a) (0.10-100 μg/mL, 24 h) shows negligible cytotoxicity against HepG2, with an IC₅₀ of >50 μM^[1].
DXR-IN-2 (0.5 ng/mL-100 μg/mL, 3 days) inhibits Plasmodium falciparum 3D7 growth by inhibiting the MEP pathway via DXR^[1].
DXR-IN-2 (1 μM) remains stable in mouse liver microsomes for more than 1 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

257.18

C₁₀H₁₂NO₅P

2260608-07-7

O=C(C1=CC=CC=C1)N(C/C=C/P(O)(O)=O)O

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• [1]. Wang X, et al. MEPicides: α,β-unsaturated Fosmidomycin N-Acyl Analogs as Efficient Inhibitors of Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate reductoisomerase. ACS Infect Dis. 2023, 9(7):1387-1395.  [Content Brief]