2. GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease
  3. Opioid Receptor Endogenous Metabolite
  4. Dynorphin A (1-8)

Dynorphin A (1-8) is the predominant opioid peptide identified in placental tissue extracts. Dynorphin A (1-8) is the most likely natural ligand of the kappa receptor. The binding of 3H-Bremazocine to the purified kappa receptor is inhibited by Dynorphin A (1-8) (IC50=303 nM).

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Dynorphin A (1-8) Chemical Structure

Dynorphin A (1-8) Chemical Structure

CAS No. : 75790-53-3

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Based on 1 publication(s) in Google Scholar

Dynorphin A (1-8) Related Antibodies

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

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Description

Dynorphin A (1-8) is the predominant opioid peptide identified in placental tissue extracts. Dynorphin A (1-8) is the most likely natural ligand of the kappa receptor. The binding of 3H-Bremazocine to the purified kappa receptor is inhibited by Dynorphin A (1-8) (IC50=303 nM)[1][2].

IC50 & Target

κ Opioid Receptor/KOR

 

Human Endogenous Metabolite

 

Molecular Weight

981.15

Formula

C46H72N14O10
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile
Sequence Shortening

YGGFLRRI
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Stored under nitrogen, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (101.92 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0192 mL 5.0961 mL 10.1921 mL
5 mM 0.2038 mL 1.0192 mL 2.0384 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.88%

COA (247 KB) LCMS (93 KB) Elemental Analysis Report (106 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.0192 mL 5.0961 mL 10.1921 mL 25.4803 mL
5 mM 0.2038 mL 1.0192 mL 2.0384 mL 5.0961 mL
10 mM 0.1019 mL 0.5096 mL 1.0192 mL 2.5480 mL
15 mM 0.0679 mL 0.3397 mL 0.6795 mL 1.6987 mL
20 mM 0.0510 mL 0.2548 mL 0.5096 mL 1.2740 mL
25 mM 0.0408 mL 0.2038 mL 0.4077 mL 1.0192 mL
30 mM 0.0340 mL 0.1699 mL 0.3397 mL 0.8493 mL
40 mM 0.0255 mL 0.1274 mL 0.2548 mL 0.6370 mL
50 mM 0.0204 mL 0.1019 mL 0.2038 mL 0.5096 mL
60 mM 0.0170 mL 0.0849 mL 0.1699 mL 0.4247 mL
80 mM 0.0127 mL 0.0637 mL 0.1274 mL 0.3185 mL
100 mM 0.0102 mL 0.0510 mL 0.1019 mL 0.2548 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dynorphin A (1-8) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dynorphin A (1-8)75790-53-3Opioid ReceptorEndogenous MetabolitenaturalligandplacentaspurifiedreceptorInhibitorinhibitorinhibit

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