2. Protein Tyrosine Kinase/RTK
  3. DYRK
  4. DYRKi

DYRKi is an inhibitor of DYRK1 and DYRK1B with IC50 values of 3.7 µM and 90 nM, respectively, which is used as a potent antagonist of Hh/Gli signaling. DYRKi impairs SMO-dependent and SMO-independent oncogenic GLI activity in human medulloblastoma cells. DYRKi is promising for research of HH/GLI-associated cancers.

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DYRKi Chemical Structure

DYRKi Chemical Structure

CAS No. : 1640364-04-0

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DYRKi Related Antibodies

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Description

DYRKi is an inhibitor of DYRK1 and DYRK1B with IC50 values of 3.7 µM and 90 nM, respectively, which is used as a potent antagonist of Hh/Gli signaling. DYRKi impairs SMO-dependent and SMO-independent oncogenic GLI activity in human medulloblastoma cells. DYRKi is promising for research of HH/GLI-associated cancers[1].

Molecular Weight

430.40

Formula

C20H13F3N4O2S
CAS No.
SMILES

O=C(NC1=NC2=CC(C(F)(F)F)=CC=C2N1)C3=CSC(C4=CC=C5OCCC5=C4)=N3
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DYRKi Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DYRKi1640364-04-0DYRKDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinaseDYRK1DYRK1BHh/Gli signalingGLImedulloblastoma cellsHH/GLI-associated cancersInhibitorinhibitorinhibit

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