2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. (E)-10-Hydroxynortriptyline

(E)-10-Hydroxynortriptyline  (Synonyms: E-10-OH-NT)

Cat. No.: HY-U00050 Purity: 99.36%
SDS COA Handling Instructions

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(E)-10-Hydroxynortriptyline (E-10-OH-NT) is a metabolite of Nortriptyline (HY-B1417). Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline (HY-B0527A). E-10-OH-NT is about 50% as potent as nortriptyline as an inhibitor of the neuronal uptake of norepinephrine in vitro and exhibits less anticholinergic effects in man.

For research use only. We do not sell to patients.

(E)-10-Hydroxynortriptyline Chemical Structure

(E)-10-Hydroxynortriptyline Chemical Structure

CAS No. : 47132-16-1

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5 mg USD 400 In-stock
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Based on 1 publication(s) in Google Scholar

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(E)-10-Hydroxynortriptyline Related Antibodies

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Description

(E)-10-Hydroxynortriptyline (E-10-OH-NT) is a metabolite of Nortriptyline (HY-B1417). Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline (HY-B0527A)[1]. E-10-OH-NT is about 50% as potent as nortriptyline as an inhibitor of the neuronal uptake of norepinephrine in vitro and exhibits less anticholinergic effects in man.

Molecular Weight

279.38

Formula

C19H21NO
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1C2=CC=CC=C2/C(C3=CC=CC=C3C1)=C/CCNC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Methanol : ≥ 25 mg/mL (89.48 mM)

H2O : 3.57 mg/mL (12.78 mM; ultrasonic and warming and heat to 60°C)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5794 mL 17.8968 mL 35.7935 mL
5 mM 0.7159 mL 3.5794 mL 7.1587 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.36%

SDS (392 KB)

COA (253 KB) HNMR (274 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / Methanol 1 mM 3.5794 mL 17.8968 mL 35.7935 mL 89.4839 mL
5 mM 0.7159 mL 3.5794 mL 7.1587 mL 17.8968 mL
10 mM 0.3579 mL 1.7897 mL 3.5794 mL 8.9484 mL
Methanol 15 mM 0.2386 mL 1.1931 mL 2.3862 mL 5.9656 mL
20 mM 0.1790 mL 0.8948 mL 1.7897 mL 4.4742 mL
25 mM 0.1432 mL 0.7159 mL 1.4317 mL 3.5794 mL
30 mM 0.1193 mL 0.5966 mL 1.1931 mL 2.9828 mL
40 mM 0.0895 mL 0.4474 mL 0.8948 mL 2.2371 mL
50 mM 0.0716 mL 0.3579 mL 0.7159 mL 1.7897 mL
60 mM 0.0597 mL 0.2983 mL 0.5966 mL 1.4914 mL
80 mM 0.0447 mL 0.2237 mL 0.4474 mL 1.1185 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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(E)-10-Hydroxynortriptyline Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E)-10-Hydroxynortriptyline47132-16-1E-10-OH-NTDrug MetabolitemetaboliteantidepressantdepressionInhibitorinhibitorinhibit

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