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  4. (E)-2'-Hydroxy-3,4-dimethoxychalcone

(E)-2'-Hydroxy-3,4-dimethoxychalcone (compound 7) is a Chalcone derivative with orally active. (E)-2'-Hydroxy-3,4-dimethoxychalcone has anti-tumour activities.

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(E)-2'-Hydroxy-3,4-dimethoxychalcone Chemical Structure

(E)-2'-Hydroxy-3,4-dimethoxychalcone Chemical Structure

CAS No. : 79140-20-8

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(E)-2'-Hydroxy-3,4-dimethoxychalcone Related Antibodies

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Description

(E)-2'-Hydroxy-3,4-dimethoxychalcone (compound 7) is a Chalcone derivative with orally active. (E)-2'-Hydroxy-3,4-dimethoxychalcone has anti-tumour activities[1].

Cellular Effect
Cell Line Type Value Description References
MCF7 IC50
95 μM
Compound: 24
Growth inhibition of MCF7 cells by sulforhodamine assay
Growth inhibition of MCF7 cells by sulforhodamine assay
[PMID: 17383189]
MDCK-II IC50
4.97 μM
Compound: 5
Inhibition of human BCRP expressed in MDCK2 cells assessed as Hoechst 33342 accumulation preincubated for 30 mins by fluorimetry
Inhibition of human BCRP expressed in MDCK2 cells assessed as Hoechst 33342 accumulation preincubated for 30 mins by fluorimetry
[PMID: 22112540]
Neutrophil IC50
15 μM
Compound: 13
Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 30 mM glucose by luminol-amplified chemiluminescence method
Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 30 mM glucose by luminol-amplified chemiluminescence method
[PMID: 33006891]
Neutrophil IC50
6.4 μM
Compound: 13
Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 5.5 mM glucose by luminol-amplified chemiluminescence method
Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 5.5 mM glucose by luminol-amplified chemiluminescence method
[PMID: 33006891]
TK-10 IC50
90 μM
Compound: 24
Growth inhibition of TK10 cells by sulforhodamine assay
Growth inhibition of TK10 cells by sulforhodamine assay
[PMID: 17383189]
Molecular Weight

284.31

Formula

C17H16O4
CAS No.
SMILES

O=C(C1=CC=CC=C1O)/C=C/C2=CC=C(OC)C(OC)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(E)-2'-Hydroxy-3,4-dimethoxychalcone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E)-2'-Hydroxy-3,4-dimethoxychalcone79140-20-8OthersAnti-tumourchalconeflavonoidorallyInhibitorinhibitorinhibit

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