2. Others Vitamin D Related/Nuclear Receptor
  3. Isotope-Labeled Compounds Estrogen Receptor/ERR
  4. (E)-4-Hydroxytamoxifen-d5

(E)-4-Hydroxytamoxifen-d5  (Synonyms: (E)-Afimoxifene-d5)

Cat. No.: HY-16950BS Purity: 98.28%
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(E)-4-Hydroxytamoxifen-d5 ((E)-Afimoxifene-d5) is the deuterium labeled (E)-4-Hydroxytamoxifen. (E)-4-Hydroxytamoxifen ((E)-Afimoxifene), the less active isomer of (Z)-4-hydroxytamoxifen, is an estrogen receptor modulator.

For research use only. We do not sell to patients.

(E)-4-Hydroxytamoxifen-d<sub>5</sub> Chemical Structure

(E)-4-Hydroxytamoxifen-d5 Chemical Structure

Size Price Stock Quantity
500 μg USD 180 In-stock
1 mg USD 340 In-stock
5 mg USD 850 In-stock
10 mg USD 1380 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of (E)-4-Hydroxytamoxifen-d5:

(E)-4-Hydroxytamoxifen-d5 Related Antibodies

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View All Estrogen Receptor/ERR Isoform Specific Products:

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

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Description

(E)-4-Hydroxytamoxifen-d5 ((E)-Afimoxifene-d5) is the deuterium labeled (E)-4-Hydroxytamoxifen. (E)-4-Hydroxytamoxifen ((E)-Afimoxifene), the less active isomer of (Z)-4-hydroxytamoxifen, is an estrogen receptor modulator.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(E)-4-Hydroxytamoxifen-d5 Related Antibodies
Molecular Weight

392.54

Formula

C26H24D5NO2
Unlabeled CAS

174592-47-3
Appearance

Solid

Color

Off-white to pink

SMILES

OC1=CC=C(C=C1)/C(C2=CC=C(C=C2)OCCN(C)C)=C(C([2H])([2H])C([2H])([2H])[2H])\C3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (254.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5475 mL 12.7376 mL 25.4751 mL
5 mM 0.5095 mL 2.5475 mL 5.0950 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5475 mL 12.7376 mL 25.4751 mL 63.6878 mL
5 mM 0.5095 mL 2.5475 mL 5.0950 mL 12.7376 mL
10 mM 0.2548 mL 1.2738 mL 2.5475 mL 6.3688 mL
15 mM 0.1698 mL 0.8492 mL 1.6983 mL 4.2459 mL
20 mM 0.1274 mL 0.6369 mL 1.2738 mL 3.1844 mL
25 mM 0.1019 mL 0.5095 mL 1.0190 mL 2.5475 mL
30 mM 0.0849 mL 0.4246 mL 0.8492 mL 2.1229 mL
40 mM 0.0637 mL 0.3184 mL 0.6369 mL 1.5922 mL
50 mM 0.0510 mL 0.2548 mL 0.5095 mL 1.2738 mL
60 mM 0.0425 mL 0.2123 mL 0.4246 mL 1.0615 mL
80 mM 0.0318 mL 0.1592 mL 0.3184 mL 0.7961 mL
100 mM 0.0255 mL 0.1274 mL 0.2548 mL 0.6369 mL
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(E)-4-Hydroxytamoxifen-d5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E)-4-Hydroxytamoxifen-d5(E)-Afimoxifene-d5Isotope-Labeled CompoundsEstrogen Receptor/ERRInhibitorinhibitorinhibit

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