2. Apoptosis
  3. Ferroptosis
  4. E/Z-FETPY

E/Z-FETPY is an organo-diiron(I) complex with strong cytotoxicity in cancer cell lines. E/Z-FETPY induces ferroptosis in low-differentiated cell lines, such as A2780 cells.

For research use only. We do not sell to patients.

E/Z-FETPY Chemical Structure

E/Z-FETPY Chemical Structure

CAS No. : 3056250-97-3

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

E/Z-FETPY Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

E/Z-FETPY is an organo-diiron(I) complex with strong cytotoxicity in cancer cell lines. E/Z-FETPY induces ferroptosis in low-differentiated cell lines, such as A2780 cells[1].

In Vitro

E/Z-FETPY (72 h) shows cytotoxic potential that inhibits the growth of HCT 116, MCF7, and A2780 cells with IC50 values 4 μM, 2.1 μM, and 2.5 μM, respectively[1].
E/Z-FETPY (2.5 μM; 24-48 h) shows a time-dependent increase in iron uptake was detected upon incubation of A2780 cells. E/Z-FETPY suppresses hydrogen peroxide (H2O2) and peroxynitrite (O═NOO-) along with amplified production of superoxide anion (O2-) and nitric oxide (NO)[1].
FETPY (5 μM) induces significant morphological changes in murine B16-F1 and B16-F10 melanoma cells, leading to senescence and/or trans-differentiation into Schwann-like cells, thus significantly reducing their tumorigenic potential[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

E/Z-FETPY Related Antibodies
In Vivo

FETPY (4 mg/kg; i.p.; once a day; for 3 weeks) significantly reduces the growth rate and tumor volume in both models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8-12 weeks old C57BL/6 male or female mice injected with B16-F1 or B16-F10 cells[1]
Dosage: 4 mg/kg
Administration: i.p.; once a day; for 3 weeks
Result: Suppressed tumor growth in low- and high-grade syngeneic melanoma models.
Molecular Weight

629.25

Formula

C22H24F3Fe2N2O5S2
CAS No.
SMILES

FC(F)(S(=O)([O-])=O)F.C[s]c1[Fe]2([N]3=CC=C(N(C)C)C=C3)([])[Fe-]1([])([CH+]#O)C2=O.[+].C4CCCC4.C5CCCC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

E/Z-FETPY Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

E/Z-FETPY3056250-97-3Ferroptosisorgano-diiron(I) complexferroptosiscytotoxicityantitumor agentInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
E/Z-FETPY
Cat. No.:
HY-158336
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (0 KB) Français - FR (0 KB) Deutsch - DE (0 KB) Norwegian - NO (0 KB) Español - ES (0 KB) Swedish - SV (0 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.