(E/Z)-Icerguastat hydrochloride  (Synonyms: (E/Z)-Sephin1 hydrochloride; (E/Z)-IFB-088 hydrochloride)

(E/Z)-Icerguastat hydrochloride ((E/Z)-Sephin1 hydrochloride) is a selective inhibitor with activity that prolongs the phosphorylation effects of eIF2α. (E/Z)-Icerguastat hydrochloride protects cells from defects in proteostasis. (E/Z)-Icerguastat hydrochloride was shown to significantly extend the survival of infected prion mice in a mouse model. (E/Z)-Icerguastat hydrochloride effectively reduces PrPSc expression and prion sequence activity in various neuronal cell lines persistently infected with different prion strains^[1].

233.10

C₈H₁₀Cl₂N₄

32597-86-7

ClC1=CC=CC=C1/C=N/NC(N)=N.Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Das I, et al. Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science. 2015 Apr 10;348(6231):239-42.  [Content Brief]

  [2]. Sephin1 Reduces Prion Infection in Prion-Infected Cells and Animal Model  [Content Brief]