2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH

Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH  (Synonyms: Cereblon Ligand-Linker Conjugates 14; E3 ligase Ligand-Linker Conjugates 49)

Cat. No.: HY-128848 Purity: 95.02%
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Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.

For research use only. We do not sell to patients.

Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH Chemical Structure

Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH Chemical Structure

CAS No. : 2351103-63-2

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10 mg USD 95 In-stock
25 mg USD 185 In-stock
50 mg USD 300 In-stock
100 mg USD 480 In-stock
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Based on 1 publication(s) in Google Scholar

Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH Related Antibodies

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View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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Description

Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.

IC50 & Target[1]

Cereblon

 

Molecular Weight

648.70

Formula

C31H44N4O11
CAS No.
Appearance

Oil

Color

Light brown to brown

SMILES

O=C(NC1=O)CCC1N(C2=O)C(C3=C2C(NCCNC(COCCCCCOCCOCCCCCOCC(O)=O)=O)=CC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 55 mg/mL (84.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5415 mL 7.7077 mL 15.4154 mL
5 mM 0.3083 mL 1.5415 mL 3.0831 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5415 mL 7.7077 mL 15.4154 mL 38.5386 mL
5 mM 0.3083 mL 1.5415 mL 3.0831 mL 7.7077 mL
10 mM 0.1542 mL 0.7708 mL 1.5415 mL 3.8539 mL
15 mM 0.1028 mL 0.5138 mL 1.0277 mL 2.5692 mL
20 mM 0.0771 mL 0.3854 mL 0.7708 mL 1.9269 mL
25 mM 0.0617 mL 0.3083 mL 0.6166 mL 1.5415 mL
30 mM 0.0514 mL 0.2569 mL 0.5138 mL 1.2846 mL
40 mM 0.0385 mL 0.1927 mL 0.3854 mL 0.9635 mL
50 mM 0.0308 mL 0.1542 mL 0.3083 mL 0.7708 mL
60 mM 0.0257 mL 0.1285 mL 0.2569 mL 0.6423 mL
80 mM 0.0193 mL 0.0963 mL 0.1927 mL 0.4817 mL
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Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH2351103-63-2Cereblon Ligand-Linker Conjugates 14 E3 ligase Ligand-Linker Conjugates 49E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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