E6 Berbamine (Synonyms: Berbamine p-nitrobenzoate)

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E6 Berbamine (Berbamine p-nitrobenzoate) is a potent calmodulin (CaM) antagonist. E6 Berbamine inhibits the activity of calmodulin (CaM)-dependent myosin light chain kinase (MLCK), with a K_i of 0.95 μM. E6 Berbamine also shows anti-leukemia activities, with an IC₅₀ of 2.13 μM in K562 cells.

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E6 Berbamine Chemical Structure

CAS No. : 114784-59-7

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Description

E6 Berbamine (Berbamine p-nitrobenzoate) is a potent calmodulin (CaM) antagonist. E6 Berbamine inhibits the activity of calmodulin (CaM)-dependent myosin light chain kinase (MLCK), with a K_i of 0.95 μM^[1]. E6 Berbamine also shows anti-leukemia activities, with an IC₅₀ of 2.13 μM in K562 cells^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
K562	IC₅₀	2.13 μM Compound: 3n	Cytotoxicity against human imatinib-resistant K562 leukemia cells expressing p210Bcr/Abl and MDR1 at 48 hrs by MTT assay Cytotoxicity against human imatinib-resistant K562 leukemia cells expressing p210Bcr/Abl and MDR1 at 48 hrs by MTT assay	[PMID: 19285759]

Molecular Weight

757.83

Formula

C₄₄H₄₃N₃O₉

CAS No.

114784-59-7

SMILES

COC1=C(OC2=CC3=C(C=C2OC)CCN4C)C5=C(C=C1OC)CCN(C)[C@@]5(CC6=CC=C(C(OC7=CC=C(C=C7)C[C@@]34[H])=C6)OC(C8=CC=C(C=C8)[N+]([O-])=O)=O)[H]

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Z Y Hu, et al. Interaction of berbamine compound E6 and calmodulin-dependent myosin light chain kinase. Biochem Pharmacol. 1992 Oct 20;44(8):1543-7. [Content Brief]

[2]. Jinwen Xie, et al. Berbamine derivatives: a novel class of compounds for anti-leukemia activity. Eur J Med Chem. 2009 Aug;44(8):3293-8. [Content Brief]

E6 Berbamine Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

E6 Berbamine114784-59-7Berbamine p-nitrobenzoateCalmodulinCaMCalcium-modulated proteincalmodulin antagonistMLCKanti-leukemia activitiesInhibitorinhibitorinhibit

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