E7766 disodium 

E7766 disodium is a macrocycle-bridged STING agonist with a K_d of 40 nM. E7766 disodium shows potent pan-genotypic and antitumor activities^[1].

E7766 disodium inhibits four human STING variants, human wild-type, HAQ, AQ and REF STING proteins, with EC₅₀ values of 1 μM, 2.2 μM, 1.2 μM and 4.9 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In murine colon cancer model, a single intratumoral injection of 10 mg/kg E7766 disodium in the subcutaneous tumor. E7766 disodium is shown to have potent antitumor activity with long lasting immune memory response in a mouse liver metastatic tumor model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

792.58

C₂₄H₂₆F₂N₁₀Na₂O₈P₂S₂

2242636-28-6

F[C@@H]1[C@H](O[P@]2(S)=O)[C@@H](CO[P@]3(S)=O)O[C@H]1[N@]4C5=NC=NC(NC/C=C/CNC6=C(N=C[N@]7[C@@H]8O[C@H](CO2)[C@@H](O3)[C@H]8F)C7=NC=N6)=C5N=C4.[Na].[Na]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Dae-Shik Kim, et al. E7766, a Macrocycle-Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan-Genotypic Activity. ChemMedChem. 2021 Jun 7;16(11):1740-1743.  [Content Brief]