2. PROTAC
  3. Ligands for Target Protein for PROTAC
  4. EA-89

EA-89 is a potent and selective BRD9 inhibitor with antitumor activity. EA-89 is a Ligand for Target Protein for PROTAC. EA-89 can be used to synthesize PROTAC QA-68 (HY-150797).

For research use only. We do not sell to patients.

EA-89 Chemical Structure

EA-89 Chemical Structure

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EA-89 Related Antibodies

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Description

EA-89 is a potent and selective BRD9 inhibitor with antitumor activity. EA-89 is a Ligand for Target Protein for PROTAC. EA-89 can be used to synthesize PROTAC QA-68 (HY-150797)[1].

IC50 & Target

BRD9[1]
In Vitro

EA-89 (0-3.2 μM; 1-7 days) inhibits cell proliferation and expression of BRD9, c-MYC and c-MYB in human leukemia cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EA-89 Related Antibodies

Western Blot Analysis[1]

Cell Line: SKM-1 cells
Concentration: 0, 10, 100, 1000 nM
Incubation Time: 24 h
Result: Reduced the levels of c-MYC and c-MYB.
Molecular Weight

594.79

Formula

C31H38N4O4S2
SMILES

CCCN1C=C(C2=CC=C(N(CC3CCNCC3)C=C4C)C4=C2)C5=C(C=C(S5)C(NC6CCS(CC6)(=O)=O)=O)C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EA-89 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EA-89EA89EA 89Ligands for Target Protein for PROTACTarget Protein-binding MoietySKM-1 cellsMV4-11 cellsInhibitorinhibitorinhibit

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EA-89
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HY-170314
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