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  4. EcDsbB-IN-10

EcDsbB-IN-10 (compound 12) is an inhibitor of EcDsbB (E. coli DsbB) enzyme, with a Ki of 0.8 nM and an IC50 of 18.85 nM.

For research use only. We do not sell to patients.

EcDsbB-IN-10 Chemical Structure

EcDsbB-IN-10 Chemical Structure

CAS No. : 112749-52-7

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5 mg USD 320 In-stock
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EcDsbB-IN-10 Related Antibodies

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Description

EcDsbB-IN-10 (compound 12) is an inhibitor of EcDsbB (E. coli DsbB) enzyme, with a Ki of 0.8 nM and an IC50 of 18.85 nM[1].

In Vitro

EcDsbB-IN-10 (compound 12) completely inhibits growth of the EcDsbB-dependent M. smegmatis strain at 400 nM, whereas the VKOR-dependent strain grew normally at concentrations up to and including 100 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EcDsbB-IN-10 Related Antibodies
Molecular Weight

289.55

Formula

C11H7Cl3N2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C(Cl)=C(C=NN1CC2=CC=CC=C2Cl)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 3 mg/mL (10.36 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4536 mL 17.2682 mL 34.5364 mL
5 mM 0.6907 mL 3.4536 mL 6.9073 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4536 mL 17.2682 mL 34.5364 mL 86.3409 mL
5 mM 0.6907 mL 3.4536 mL 6.9073 mL 17.2682 mL
10 mM 0.3454 mL 1.7268 mL 3.4536 mL 8.6341 mL
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EcDsbB-IN-10 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EcDsbB-IN-10112749-52-7OthersEcDsbBE. coli DsbBM. smegmatisInhibitorinhibitorinhibit

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EcDsbB-IN-10
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