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  5. Edrecolomab

Edrecolomab  (Synonyms: Panorex; CO17-1A)

Cat. No.: HY-P99231 Purity: 98.63%
Data Sheet
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Edrecolomab (Panorex) is a murine monoclonal antibody to the cell-surface glycoprotein 17-1A, expressed on epithelial tissues and on various carcinomas. Edrecolomab shows anti-tumor activity and can be used in colorectal carcinoma research.

For research use only. We do not sell to patients.

CAS No. : 156586-89-9

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Description

Edrecolomab (Panorex) is a murine monoclonal antibody to the cell-surface glycoprotein 17-1A, expressed on epithelial tissues and on various carcinomas. Edrecolomab shows anti-tumor activity and can be used in colorectal carcinoma research[1][2].

Isotype

Mouse IgG2a kappa
Recommend Isotype Controls
Species

Mouse
In Vitro

Edrecolomab (0-100 μg/mL; 20 h) shows moderate antibody-dependent cellular cytotoxicity (ADCC)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Edrecolomab Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: KATO III cells
Concentration: 0-100 μg/mL
Incubation Time: 20 hours
Result: Exhibited an ED50 value>100 ng/ml.
In Vivo

Edrecolomab (intravenous injection; 30 μg/dose; day 1, 4 and 7 after tumor-cell inoculation) treatment inhibits tumor growth in the HT-29 nude mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male nu/nu mice injected with HT-29 colon carcinoma cells[1]
Dosage: 30 μg/dose
Administration: Intravenous injection; 30 μg/dose; day 1, 4 and 7 after tumor-cell inoculation
Result: Inhibited tumor growth with a number of significant readings (p≤0.05).
Clinical Trial
NCT NumberSponsorConditionStart DatePhase
NCT00002968National Cancer Institute (NCI)
Mucinous Adenocarcinoma of the Colon|Signet Ring Adenocarcinoma of the Colon|Stage IIA Colon Cancer|Stage IIB Colon Cancer|Stage IIC Colon Cancer
May 1997Phase 3
NCT00002664James Ahlgren|George Washington University
Colorectal Cancer
July 1995Phase 2
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Edrecolomab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • IgG2a-kappa
Purity & Documentation
References
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Keywords:

Edrecolomab156586-89-9Panorex CO17-1AOthersglycoprotein 17-1Aanti-tumor activitycolorectal carcinomaKATO III cellInhibitorinhibitorinhibit

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