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  3. Isotope-Labeled Compounds
  4. EDTA-d12

EDTA-d12  (Synonyms: Ethylenediaminetetraacetic acid-d12)

Cat. No.: HY-Y0682S Purity: 98.00%
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EDTA-d12 is the deuterium labeled Ethylenediaminetetraacetic acid[1]. Ethylenediaminetetraacetic acid (EDTA) is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can also decrease the formation of disulfide bonds[2][3][4].

For research use only. We do not sell to patients.

EDTA-d<sub>12</sub> Chemical Structure

EDTA-d12 Chemical Structure

CAS No. : 203806-08-0

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Based on 1 publication(s) in Google Scholar

Other Forms of EDTA-d12:

EDTA-d12 Related Antibodies

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Description

EDTA-d12 is the deuterium labeled Ethylenediaminetetraacetic acid[1]. Ethylenediaminetetraacetic acid (EDTA) is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can also decrease the formation of disulfide bonds[2][3][4].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EDTA-d12 Related Antibodies
Molecular Weight

304.32

Formula

C10H4D12N2O8
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(C([2H])([2H])N(C([2H])([2H])C(O)=O)C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C(O)=O)C([2H])([2H])C(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

0.1 M NaOH : 6.67 mg/mL (21.92 mM; ultrasonic and warming and adjust pH to 7 with NaOH)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2860 mL 16.4301 mL 32.8601 mL
5 mM 0.6572 mL 3.2860 mL 6.5720 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
0.1 M NaOH 1 mM 3.2860 mL 16.4301 mL 32.8601 mL 82.1504 mL
5 mM 0.6572 mL 3.2860 mL 6.5720 mL 16.4301 mL
10 mM 0.3286 mL 1.6430 mL 3.2860 mL 8.2150 mL
15 mM 0.2191 mL 1.0953 mL 2.1907 mL 5.4767 mL
20 mM 0.1643 mL 0.8215 mL 1.6430 mL 4.1075 mL
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EDTA-d12 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EDTA-d12203806-08-0Ethylenediaminetetraacetic acid-d12Isotope-Labeled CompoundsInhibitorinhibitorinhibit

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