2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Metabolic Enzyme/Protease Apoptosis
  3. EGFR Dihydrofolate reductase (DHFR) Apoptosis
  4. EGFR/HER2/DHFR-IN-3

EGFR/HER2/DHFR-IN-3 (compound 4c) is a potent dual inhibitor of EGFR/HER2, with IC50s of 0.138 and 0.092 μM, respectively. EGFR/HER2/DHFR-IN-3 also inhibits DHFR, with an IC50 of 0.193 M. EGFR/HER2/DHFR-IN-3 causes arrest at the S phase of the cell cycle and induces apoptosis in MCF7 breast cancer cells.

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EGFR/HER2/DHFR-IN-3 Chemical Structure

EGFR/HER2/DHFR-IN-3 Chemical Structure

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EGFR/HER2/DHFR-IN-3 Related Antibodies

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Description

EGFR/HER2/DHFR-IN-3 (compound 4c) is a potent dual inhibitor of EGFR/HER2, with IC50s of 0.138 and 0.092 μM, respectively. EGFR/HER2/DHFR-IN-3 also inhibits DHFR, with an IC50 of 0.193 M. EGFR/HER2/DHFR-IN-3 causes arrest at the S phase of the cell cycle and induces apoptosis in MCF7 breast cancer cells[1].

IC50 & Target[1]

EGFR

0.138 μM (IC50)

HER2

0.092 μM (IC50)

DHFR

0.193 μM (IC50)

Molecular Weight

373.40

Formula

C22H19N3O3
SMILES

N#CC1=C(OCCC)N=C(C2=CC=C(C)C=C2)C=C1C3=CC=C([N+]([O-])=O)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EGFR/HER2/DHFR-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR/HER2/DHFR-IN-3EGFRDihydrofolate reductase (DHFR)ApoptosisEpidermal growth factor receptorErbB-1HER1S phasecell cyclebreast cancerInhibitorinhibitorinhibit

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