2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EGFR/HER2-IN-10

EGFR/HER2-IN-10 (compound 9F) is a potent and selective dual EGFR/HER2 inhibitor with IC50s of 2.3 nM and 234 nM for EGFR and HER2, respectively. EGFR/HER2-IN-10 shows an effective antiproliferative action against prostate carcinoma.

For research use only. We do not sell to patients.

EGFR/HER2-IN-10 Chemical Structure

EGFR/HER2-IN-10 Chemical Structure

CAS No. : 2931499-82-8

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EGFR/HER2-IN-10 Related Antibodies

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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Description

EGFR/HER2-IN-10 (compound 9F) is a potent and selective dual EGFR/HER2 inhibitor with IC50s of 2.3 nM and 234 nM for EGFR and HER2, respectively. EGFR/HER2-IN-10 shows an effective antiproliferative action against prostate carcinoma[1].

IC50 & Target[1]

EGFR

2.3 nM (IC50)

HER2

234 nM (IC50)

Molecular Weight

628.99

Formula

C29H24ClF3N6O5
CAS No.
SMILES

O=[N+](C1=NC=CN1CCCCOC2=CC3=C(NC4=CC=C(OC5=CC=CC(C(F)(F)F)=C5)C(Cl)=C4)N=CN=C3C=C2OC)[O-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EGFR/HER2-IN-10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR/HER2-IN-102931499-82-8EGFREpidermal growth factor receptorErbB-1HER1EGFR/HER2 inhibitorantiproliferative actionInhibitorinhibitorinhibit

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