1. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  2. EGFR
  3. EGFR/HER2-IN-14

EGFR/HER2-IN-14 (Compd 46) is an inhibitor of mutant EGFR/HER2s which are resistant to other drugs. EGFR/HER2-IN-14 can be used for cancer research.

For research use only. We do not sell to patients.

EGFR/HER2-IN-14 Chemical Structure

EGFR/HER2-IN-14 Chemical Structure

CAS No. : 3034701-54-4

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Description

EGFR/HER2-IN-14 (Compd 46) is an inhibitor of mutant EGFR/HER2s which are resistant to other drugs. EGFR/HER2-IN-14 can be used for cancer research[1].

In Vitro

EGFR/HER2-IN-14 shows IC50s bellow 100 nM against EGFR exon 20 insASV/insSVD, HER2 exon 20 insGSP/insYVMA mutants EGFR/HER2s transformed Ba/F3 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

575.62

Formula

C32H29N7O4

CAS No.
SMILES

COC1=C(NC2=NC=C3C(N(C4=CC=CC(NC(C=C)=O)=C4)C(C(C5=CC=CC=C5)=C3)=O)=N2)C=CC(N6CCOCC6)=N1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
EGFR/HER2-IN-14
Cat. No.:
HY-161603
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