EGFR/HER2-IN-16

Cat. No.: HY-159519: FAQs
Data Sheet Handling Instructions

Molarity Calculator

EGFR/HER2-IN-16 (compound 12K) is an effective dual-target inhibitor of EGFR (IC₅₀=6.15 nM) and HER-2 (IC₅₀=9.78 nM) with anti-tumor activity. EGFR/HER2-IN-16 can inhibit the migration of SK-BR-3 cells, arrest the cell cycle in the G0/G1 phase, and induce apoptosis. EGFR/HER2-IN-16 exhibits good anti-proliferative activity against tumor cell models and has little damage to healthy cells. EGFR/HER2-IN-16 can be used in breast cancer research.

For research use only. We do not sell to patients.

EGFR/HER2-IN-16 Chemical Structure

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MOQ		Minimum order quantity
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Synthetic products have potential research and development risk.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

EGFR

6.15 nM (IC₅₀)

HER1

9.78 nM (IC₅₀)

Molecular Weight

554.44

Formula

C₂₉H₂₄BrN₅O₂

SMILES

O=C(C1=CC=CC(Br)=C1)N2CCN(C3=CC=CC(NC4=C5C=C(C6=CC=CO6)C=CC5=NC=N4)=C3)CC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Shuang Hao, et al. "Design, synthesis and biological evaluation of novel quinazoline-derived EGFR/HER-2 dual-target inhibitors bearing a heterocyclic-containing tail as potential anti-tumor agents." Bioorganic Chemistry (2024): 107686. [Content Brief]

EGFR/HER2-IN-16 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR/HER2-IN-16ApoptosisEGFREpidermal growth factor receptorErbB-1HER1HER-2inhibitoranti-tumorapoptosisanti-proliferationbreast cancerSK-BR-3 cellsInhibitorinhibit

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