2. Apoptosis Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. Apoptosis EGFR
  4. EGFR/HER2-IN-16

EGFR/HER2-IN-16 (compound 12K) is an effective dual-target inhibitor of EGFR (IC50=6.15 nM) and HER-2 (IC50=9.78 nM) with anti-tumor activity. EGFR/HER2-IN-16 can inhibit the migration of SK-BR-3 cells, arrest the cell cycle in the G0/G1 phase, and induce apoptosis. EGFR/HER2-IN-16 exhibits good anti-proliferative activity against tumor cell models and has little damage to healthy cells. EGFR/HER2-IN-16 can be used in breast cancer research.

For research use only. We do not sell to patients.

EGFR/HER2-IN-16 Chemical Structure

EGFR/HER2-IN-16 Chemical Structure

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EGFR/HER2-IN-16 Related Antibodies

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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Description

EGFR/HER2-IN-16 (compound 12K) is an effective dual-target inhibitor of EGFR (IC50=6.15 nM) and HER-2 (IC50=9.78 nM) with anti-tumor activity. EGFR/HER2-IN-16 can inhibit the migration of SK-BR-3 cells, arrest the cell cycle in the G0/G1 phase, and induce apoptosis. EGFR/HER2-IN-16 exhibits good anti-proliferative activity against tumor cell models and has little damage to healthy cells. EGFR/HER2-IN-16 can be used in breast cancer research[1].

IC50 & Target[1]

EGFR

6.15 nM (IC50)

HER1

9.78 nM (IC50)

Molecular Weight

554.44

Formula

C29H24BrN5O2
SMILES

O=C(C1=CC=CC(Br)=C1)N2CCN(C3=CC=CC(NC4=C5C=C(C6=CC=CO6)C=CC5=NC=N4)=C3)CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EGFR/HER2-IN-16 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR/HER2-IN-16ApoptosisEGFREpidermal growth factor receptorErbB-1HER1HER-2inhibitoranti-tumorapoptosisanti-proliferationbreast cancerSK-BR-3 cellsInhibitorinhibit

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