1. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis
  2. EGFR Thymidylate Synthase
  3. EGFR/HER2/TS-IN-2

EGFR/HER2/TS-IN-2 (compound 17) is a potent EGFR/HER2 and TS (Thymidylate synthase) inhibitor, with IC50 values of 0.173, 0.125, and 1.12 μM, respectively. EGFR/HER2/TS-IN-2 shows cytotoxic activity against MDA-MB-231 cancer cell lines, with an IC50 of 1.69 µM.

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EGFR/HER2/TS-IN-2 Chemical Structure

EGFR/HER2/TS-IN-2 Chemical Structure

CAS No. : 2444364-04-7

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Description

EGFR/HER2/TS-IN-2 (compound 17) is a potent EGFR/HER2 and TS (Thymidylate synthase) inhibitor, with IC50 values of 0.173, 0.125, and 1.12 μM, respectively. EGFR/HER2/TS-IN-2 shows cytotoxic activity against MDA-MB-231 cancer cell lines, with an IC50 of 1.69 µM[1].

IC50 & Target

HER2

0.125 ± 0. μM (IC50)

EGFR

0.173 ± 0. μM (IC50)

In Vitro

EGFR/HER2/TS-IN-2 (compound 17) shows the GI (growth inhibition)=53.20 and 49.35% towards ovarian cancer IGROV1 and renal cancer UO-31, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

511.62

Formula

C26H21N7OS2

CAS No.
SMILES

N#CC1=C(N2N=C(C)C=C2C)N=C(SCC(NC3=NC4=C(S3)C=C(C)C=C4)=O)N=C1C5=CC=CC=C5

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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EGFR/HER2/TS-IN-2
Cat. No.:
HY-146239
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