EGFR/HER2/TS-IN-2

Cat. No.: HY-146239: FAQs
Data Sheet Handling Instructions

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EGFR/HER2/TS-IN-2 (compound 17) is a potent EGFR/HER2 and TS (Thymidylate synthase) inhibitor, with IC₅₀ values of 0.173, 0.125, and 1.12 μM, respectively. EGFR/HER2/TS-IN-2 shows cytotoxic activity against MDA-MB-231 cancer cell lines, with an IC₅₀ of 1.69 µM.

For research use only. We do not sell to patients.

EGFR/HER2/TS-IN-2 Chemical Structure

CAS No. : 2444364-04-7

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

HER2

0.125 ± 0. μM (IC₅₀)

EGFR

0.173 ± 0. μM (IC₅₀)

In Vitro

EGFR/HER2/TS-IN-2 (compound 17) shows the GI (growth inhibition)=53.20 and 49.35% towards ovarian cancer IGROV1 and renal cancer UO-31, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

511.62

Formula

C₂₆H₂₁N₇OS₂

CAS No.

2444364-04-7

SMILES

N#CC1=C(N2N=C(C)C=C2C)N=C(SCC(NC3=NC4=C(S3)C=C(C)C=C4)=O)N=C1C5=CC=CC=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Abdellatif KRA, et al. Design, synthesis, molecular docking and antiproliferative activity of some novel benzothiazole derivatives targeting EGFR/HER2 and TS. Bioorg Chem. 2020 Aug;101:103976. [Content Brief]

EGFR/HER2/TS-IN-2 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR/HER2/TS-IN-22444364-04-7EGFRThymidylate SynthaseEpidermal growth factor receptorErbB-1HER1BenzothiazoleCyano pyrimidineDual EGFR/HER2 inhibitorMultitargetThymidylate synthaseAntitumor activityhuman epidermal growth factor receptor 2Inhibitorinhibitorinhibit

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