2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis
  3. EGFR Apoptosis
  4. EGFR-IN-108 chloride

EGFR-IN-108 chloride (Compound Ru3S) is an EGFR inhibitor with an IC50 value of 5.8 nM for hEGFR. EGFR-IN-108 chloride induces apoptosis and has anti-proliferative activity against cancer cells. EGFR-IN-108 chloride also has anti-angiogenic effects.

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EGFR-IN-108 chloride Chemical Structure

EGFR-IN-108 chloride Chemical Structure

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EGFR-IN-108 chloride Related Antibodies

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Description

EGFR-IN-108 chloride (Compound Ru3S) is an EGFR inhibitor with an IC50 value of 5.8 nM for hEGFR. EGFR-IN-108 chloride induces apoptosis and has anti-proliferative activity against cancer cells. EGFR-IN-108 chloride also has anti-angiogenic effects[1].

In Vitro

Ru4S (0.2-100 μM; 48 h) shows cytotoxicity on HepG2, Caco-2, HT-29, MCF-7, A549, HEK293T cells, with IC50 values of 23.76, 2.47, 6.24, 5.35, 29.90, 33.15 μM respectively[1].
Ru4S (0.78-50 μM; 48 h) induces apoptosis in HepG2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR-IN-108 chloride Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HepG2, Caco-2, HT-29, MCF-7, A549, HEK293T cells
Concentration: 0.2-100 μM
Incubation Time: 48 h
Result: exhibited cytotoxicity.

Cell Proliferation Assay[1]

Cell Line: HepG2 cells
Concentration: 0.78, 3.12, 12.5, and 50 μM
Incubation Time: 48 h
Result: increased Sub G1 (p < 0.0001) and decreased G0/G1, S, and G2/M percentages (p < 0.05) at 0.78 μM. And slightly increased Sub G1 (p < 0.01), slightly decreased G0/G1 (p < 0.01), and decreased G2/M (p < 0.05) at 3.12 and 12.5 μM. Increased Sub G1(p < 0.0001) and decreased S (p < 0.01), and did not affect the G0/G1 and G2/M phases at 50 μM.
Molecular Weight

1005.28

Formula

C45H40Cl3F3N8O3Ru
SMILES

CC1=[N]2[Ru+2]3([N]4=C(C)C=CC=C4C5=CC=CC(C)=[N]35)([N]6=CC=C(OC7=CC=C(NC(NC8=CC=C(Cl)C(C(F)(F)F)=C8)=O)C=C7)C=C6C9=O)([NH]9C)[N]%10=C(C)C=CC=C%10C2=CC=C1.[Cl-].[Cl-]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EGFR-IN-108 chloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-108EGFRApoptosisEpidermal growth factor receptorErbB-1HER1HepG2 cellsCaco-2 cellsHT-29 cellsMCF-7 cellscytotoxicitycell cycleInhibitorinhibitorinhibit

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EGFR-IN-108 chloride
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