EGFR-IN-120 

EGFR-IN-120 (Compound 11eg) is an orally active EGFR inhibitor. EGFR-IN-120 inhibits EGFR^{L858R/T790M/C797S} with an IC₅₀ value of 0.053 μM, and has a relatively weak effect on EGFR^WT (IC₅₀: 1.05 μM). EGFR-IN-120 inhibits the phosphorylation of EGFR and main downstream effectors (STAT3, AKT, and Erk). EGFR-IN-120 induces cell cycle arrest and cell apoptosis in EGFR mutant cells. EGFR-IN-120 inhibits the proliferation of the NSCLC cells harboring EGFR^{L858R/T790M/C797S} with an IC₅₀ of 0.052 μM^[1].

570.66

C₃₁H₃₅FN₈O₂

FC1=C(C2=CC=C(C=C(C(NC)=O)N3C(C)C)C3=C2)N=C(NC4=CC=C(N5CCN(C)CC5)C(NC(C=C)=O)=C4)N=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wang X, et al. Novel EGFR inhibitors against resistant L858R/T790M/C797S mutant for intervention of non-small cell lung cancer. Eur J Med Chem. 2024 Jul 26;277:116711.  [Content Brief]