2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EGFR-IN-127

EGFR-IN-127 is an ATP-competitive EGFR inhibitor with IC50s of 136.3 nM and 161. 2 nM for EGFRdel19 and EGFRdel19/T790M/C797S, respectively. EGFR-IN-127 has the potential for the study of non-small-cell lung cancer (NSCLC).

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EGFR-IN-127 Chemical Structure

EGFR-IN-127 Chemical Structure

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EGFR-IN-127 Related Antibodies

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Description

EGFR-IN-127 is an ATP-competitive EGFR inhibitor with IC50s of 136.3 nM and 161. 2 nM for EGFRdel19 and EGFRdel19/T790M/C797S, respectively. EGFR-IN-127 has the potential for the study of non-small-cell lung cancer (NSCLC)[1].

IC50 & Target[1]

EGFRex19del

136.3 nM (IC50)

EGFR19del/TM/CS

161.2 nM (IC50)

In Vitro

EGFR-IN-127 (compound b) inhibits the lung cancer cell proliferation of A549, PC-9del19, PC-9del19/T790M/C797S, and H1975 cells,with IC50 values of 0.9464 μM, 1.1262 μM, 0.4963 μM, and 1.4142 μM, respectively[1].
EGFR-IN-127 (100 nM-1 μM; 48 h) shows a noticeable inhibition of cell migration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR-IN-127 Related Antibodies

Cell Migration Assay [1]

Cell Line: PC-9del19/T790M/C797S cells.
Concentration: 100 nM and 1 μM
Incubation Time: 48 h
Result: Revealed a noticeable inhibition of cell migration.
Molecular Weight

525.49

Formula

C24H24FN7O6
SMILES

O=C(O)CN(CCN(CC(O)=O)C1)CC(NC2=CC3=C(N=CN=C3NC4=CC(F)=CC=C4)C=C2NC1=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EGFR-IN-127 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-127EGFREpidermal growth factor receptorErbB-1HER1EGFR inhibitorEGFR triple mutantsATP-competitivecell migrationInhibitorinhibitorinhibit

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EGFR-IN-127
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HY-168112
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