2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Cytoskeleton Cell Cycle/DNA Damage Immunology/Inflammation Apoptosis
  3. EGFR Microtubule/Tubulin Interleukin Related TNF Receptor Apoptosis
  4. EGFR-IN-144

EGFR-IN-144 (Compound 4B) exhibits inhibitory activities against EGFR (IC50=0.639 µg/mL) and tubulin polymerization (IC50=7.339 µg/mL). EGFR-IN-144 exhibits cytotoxicity in multiple cancer cell with GI50 of nanomolare levels. EGFR-IN-144 downregulates the expressions of mTOR, TNF-α, and IL-6, arrests the cell cycle at G1/S phase, and induces apoptosis.

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EGFR-IN-144 Chemical Structure

EGFR-IN-144 Chemical Structure

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EGFR-IN-144 Related Antibodies

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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Description

EGFR-IN-144 (Compound 4B) exhibits inhibitory activities against EGFR (IC50=0.639 µg/mL) and tubulin polymerization (IC50=7.339 µg/mL). EGFR-IN-144 exhibits cytotoxicity in multiple cancer cell with GI50 of nanomolare levels. EGFR-IN-144 downregulates the expressions of mTOR, TNF-α, and IL-6, arrests the cell cycle at G1/S phase, and induces apoptosis[1].

Molecular Weight

418.27

Formula

C20H17Cl2N3O3
SMILES

COC1=CC=C(C=C1OC)/C=C/C(C2=C(N(N=N2)C3=C(Cl)C=C(Cl)C=C3)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EGFR-IN-144 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-144EGFRMicrotubule/TubulinInterleukin RelatedTNF ReceptorApoptosisEpidermal growth factor receptorErbB-1HER1ILTumor Necrosis Factor ReceptorTNFRMelanomacolorectal cancerHCT-116Inhibitorinhibitorinhibit

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EGFR-IN-144
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HY-172111
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