2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EGFR-IN-36

EGFR-IN-36 is a potent EGFR inhibitor with IC50s of 19.09 nM, 120.01 nM, 2.35 nM for EGFR (WT), HER2 (WT), HER2 (A775_G776insYVMA), respectively. EGFR-IN-36 has potential for wild and/or mutant EGFR and/or HER2 kinase mediated tumors research.

For research use only. We do not sell to patients.

EGFR-IN-36 Chemical Structure

EGFR-IN-36 Chemical Structure

CAS No. : 2711105-54-1

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EGFR-IN-36 Related Antibodies

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Description

EGFR-IN-36 is a potent EGFR inhibitor with IC50s of 19.09 nM, 120.01 nM, 2.35 nM for EGFR (WT), HER2 (WT), HER2 (A775_G776insYVMA), respectively. EGFR-IN-36 has potential for wild and/or mutant EGFR and/or HER2 kinase mediated tumors research[1].

IC50 & Target[1]

EGFR (WT)

19.09 nM (IC50)

HER2(WT)

120.01 nM (IC50)

HER2 (A775_G776insYVMA)

2.35 nM (IC50)

In Vitro

EGFR-IN-36 (compound 8) inhibits A431 cell (IC50=223.6 nM),A549 cell (IC50=7644.42 nM), H1975 cell (IC50=20.68 nM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR-IN-36 Related Antibodies
Molecular Weight

488.97

Formula

C26H25ClN6O2
CAS No.
SMILES

C=CC(N1CC(C2=CC(C3=CC=C(OCC4=NC=CC=C4)C(Cl)=C3)=C5C(N)=NC=NN52)CCC1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EGFR-IN-36 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-362711105-54-1EGFREpidermal growth factor receptorErbB-1HER1GFR(WT)HER2(WT) HER2(A775_G776insYVMA),A431,A549H1975Inhibitorinhibitorinhibit

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HY-144053
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