2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EGFR-IN-55

EGFR-IN-55 (Compound 8a) is a potent EGFR inhibitor with IC50 values of 70 nM and 3.9 nM against EGFRWT and EGFRL858R/T790M, respectively. EGFR-IN-55 arrests NCI-H1975 cells in G0/G1 phase and shows anticancer activity.

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EGFR-IN-55 Chemical Structure

EGFR-IN-55 Chemical Structure

CAS No. : 2057423-46-6

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EGFR-IN-55 Related Antibodies

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Description

EGFR-IN-55 (Compound 8a) is a potent EGFR inhibitor with IC50 values of 70 nM and 3.9 nM against EGFRWT and EGFRL858R/T790M, respectively. EGFR-IN-55 arrests NCI-H1975 cells in G0/G1 phase and shows anticancer activity[1].

IC50 & Target

EGFRL858R/T790M

3.9 nM (IC50)

EGFRWT

70 nM (IC50)

Molecular Weight

526.42

Formula

C25H25Cl2N7O2
CAS No.
SMILES

C=C(Cl)C(NC1=CC=CC(NC2=NC(NC3=CC=C(N4CCN(C(C)=O)CC4)C=C3)=NC=C2Cl)=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EGFR-IN-55 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-552057423-46-6EGFREpidermal growth factor receptorErbB-1HER1NCI-H1975A431non-small cell lung cancerInhibitorinhibitorinhibit

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