2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EGFR-IN-80

EGFR-IN-80 (compound 30) is an EGFR inhibitor with a pIC50 of 10.6.

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EGFR-IN-80 Chemical Structure

EGFR-IN-80 Chemical Structure

CAS No. : 171745-13-4

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Based on 1 publication(s) in Google Scholar

EGFR-IN-80 Related Antibodies

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Description

EGFR-IN-80 (compound 30) is an EGFR inhibitor with a pIC50 of 10.6[1].

IC50 & Target[1]

EGFR

10.6 (pIC50)

Cellular Effect
Cell Line Type Value Description References
A-431 IC50
0.006 nM
Compound: 13
Inhibition of the phosphorylation of a random polyglutamic acid/tyrosine copolymer by human epidermal growth factor receptor(EGFR) prepared from human A431 carcinoma cells
Inhibition of the phosphorylation of a random polyglutamic acid/tyrosine copolymer by human epidermal growth factor receptor(EGFR) prepared from human A431 carcinoma cells
[PMID: 9154973]
A-431 IC50
0.006 nM
Compound: 56
Concentration required to inhibit the phosphorylation of a 14-residue fragment of phospholipase C gamma 1 by Epidermal growth factor receptor from A431 cell vesicles
Concentration required to inhibit the phosphorylation of a 14-residue fragment of phospholipase C gamma 1 by Epidermal growth factor receptor from A431 cell vesicles
[PMID: 8568816]
Molecular Weight

388.26

Formula

C18H18BrN3O2
CAS No.
SMILES

CCOC1=CC2=NC=NC(NC3=CC=CC(Br)=C3)=C2C=C1OCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EGFR-IN-80 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-80171745-13-4EGFREpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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HY-103437
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