EGFR/VEGFR2-IN-1

Cat. No.: HY-168073: FAQs
Data Sheet Handling Instructions

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EGFR/VEGFR2-IN-1 (Compound 10e) is a VEGFR-2 and EGFR inhibitor (IC₅₀: 0.26 and 0.14 μM respectively). EGFR/VEGFR2-IN-1 inhibits tubulin polymerization with an IC₅₀ of 40.9 μM. EGFR/VEGFR2-IN-1 induces apoptosis. EGFR/VEGFR2-IN-1 can be used for research of antileukemia and antilymphoma.

For research use only. We do not sell to patients.

EGFR/VEGFR2-IN-1 Chemical Structure

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

VEGFR-2

0.26 μM (IC₅₀)

Molecular Weight

465.95

Formula

C₂₄H₂₀ClN₃O₃S

SMILES

O=C(CNC(S/C1=C\C2=CC=CC=C2O)=NC1=O)N(C3=C4CCCC3)C5=C4C=C(Cl)C=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ali BS, et al. Tetrahydrocarbazoles incorporating 5-arylidene-4-thiazolinones as potential antileukemia and antilymphoma targeting tyrosine kinase and tubulin polymerase enzymes: Design, synthesis, structural, biological and molecular docking studies. Bioorg Chem. 2024 Sep 10;153:107817. [Content Brief]

EGFR/VEGFR2-IN-1 Related Classifications

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Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR/VEGFR2-IN-1EGFRVEGFRApoptosisMicrotubule/TubulinEpidermal growth factor receptorErbB-1HER1Vascular endothelial growth factor receptorInhibitorinhibitorinhibit

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