1. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis Cell Cycle/DNA Damage Cytoskeleton
  2. EGFR VEGFR Apoptosis Microtubule/Tubulin
  3. EGFR/VEGFR2-IN-1

EGFR/VEGFR2-IN-1 (Compound 10e) is a VEGFR-2 and EGFR inhibitor (IC50: 0.26 and 0.14 μM respectively). EGFR/VEGFR2-IN-1 inhibits tubulin polymerization with an IC50 of 40.9 μM. EGFR/VEGFR2-IN-1 induces apoptosis. EGFR/VEGFR2-IN-1 can be used for research of antileukemia and antilymphoma.

For research use only. We do not sell to patients.

EGFR/VEGFR2-IN-1 Chemical Structure

EGFR/VEGFR2-IN-1 Chemical Structure

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Description

EGFR/VEGFR2-IN-1 (Compound 10e) is a VEGFR-2 and EGFR inhibitor (IC50: 0.26 and 0.14 μM respectively). EGFR/VEGFR2-IN-1 inhibits tubulin polymerization with an IC50 of 40.9 μM. EGFR/VEGFR2-IN-1 induces apoptosis. EGFR/VEGFR2-IN-1 can be used for research of antileukemia and antilymphoma[1].

IC50 & Target[1]

VEGFR-2

0.26 μM (IC50)

Molecular Weight

465.95

Formula

C24H20ClN3O3S

SMILES

O=C(CNC(S/C1=C\C2=CC=CC=C2O)=NC1=O)N(C3=C4CCCC3)C5=C4C=C(Cl)C=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
EGFR/VEGFR2-IN-1
Cat. No.:
HY-168073
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