eIF4A3-IN-17

Cat. No.: HY-148451: FAQs
Data Sheet SDS COA Handling Instructions

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eIF4A3-IN-17 (compound 61) is a silvestrol (HY-13251) analogue. eIF4A3-IN-17 interferes the assembling of eIF4F translation complex with EC₅₀s of 0.9, 15 and 1.8 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-17 can be used for the research of human cancer pathogenesis.

For research use only. We do not sell to patients.

eIF4A3-IN-17 Chemical Structure

CAS No. : 1402931-75-2

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-231	EC₅₀	0.9 nM Compound: 61	Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation incubated for 24 hrs by differential translation assay Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation incubated for 24 hrs by differential translation assay	[PMID: 23025805]
MDA-MB-231	EC₅₀	1.8 nM Compound: 61	Growth inhibition of human MDA-MB-231 cells incubated for 72 hrs by MTS assay Growth inhibition of human MDA-MB-231 cells incubated for 72 hrs by MTS assay	[PMID: 23025805]
MDA-MB-231	EC₅₀	15 nM Compound: 61	Inhibition of eIF4FA in human MDA-MB-231 cells transfected with tubulin 5'-UTR-luciferase construct assessed as reduction in translation initiation incubated for 24 hrs by differential translation assay Inhibition of eIF4FA in human MDA-MB-231 cells transfected with tubulin 5'-UTR-luciferase construct assessed as reduction in translation initiation incubated for 24 hrs by differential translation assay	[PMID: 23025805]

Molecular Weight

487.50

Formula

C₂₈H₂₅NO₇

CAS No.

1402931-75-2

Appearance

Solid

Color

White to off-white

SMILES

COC1=CC=C([C@@]23OC4=CC(C#N)=CC(OC)=C4[C@]2(O)[C@@H]([C@@H]([C@H]3C5=CC=CC=C5)C(OC)=O)O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation

Purity: 99.56%

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Data Sheet (278 KB) SDS (251 KB)

COA (265 KB) HNMR (228 KB) RP-HPLC (265 KB) MS (236 KB)

Handling Instructions (2659 KB)

References

[1]. Liu T, et al. Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors. J Med Chem. 2012 Oct 25;55(20):8859-78. [Content Brief]

eIF4A3-IN-17 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

eIF4A3-IN-171402931-75-2Eukaryotic Initiation Factor (eIF)myc-LUCtub-LUCMBA-MB-231natural producttranslationInhibitorinhibitorinhibit

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