2. GPCR/G Protein
  3. Arrestin Apelin Receptor (APJ)
  4. ELA-21 (human)

ELA-21 (human) is an apelin receptor agonist with a pKi of 8.52. ELA-21 (human) completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment with subnanomolar potencies. ELA-21 (human) is an agonist in G-protein-dependent and -independent pathways.

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ELA-21 (human) Chemical Structure

ELA-21 (human) Chemical Structure

CAS No. : 2245073-05-4

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ELA-21 (human) Related Antibodies

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Description

ELA-21 (human) is an apelin receptor agonist with a pKi of 8.52. ELA-21 (human) completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment with subnanomolar potencies. ELA-21 (human) is an agonist in G-protein-dependent and -independent pathways[1].

Molecular Weight

2587.11

Formula

C112H184N40O25S3
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Leu-Arg-Lys-His-Asn-Cys-Leu-Gln-Arg-Arg-Cys-Met-Pro-Leu-His-Ser-Arg-Val-Pro-Phe-Pro (Disulfide bridge: Cys6-Cys11)
Sequence Shortening

LRKHNCLQRRCMPLHSRVPFP (Disulfide bridge: Cys6-Cys11)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Purity & Documentation
References
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ELA-21 (human) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ELA-21 (human)2245073-05-4ArrestinApelin Receptor (APJ)ApelinG-proteincAMPβ-arrestinInhibitorinhibitorinhibit

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