1. Apoptosis Immunology/Inflammation
  2. TNF Receptor IFNAR
  3. EM-163

EM-163 is a summative BB-Loop analog. EM-163 can alleviate inflammation and prevent death from toxic shock by targeting the TIR domain of MyD88. EM-163 can be used in the study of SEB poisoning (SEB: Staphylococcal enterotoxin B).

For research use only. We do not sell to patients.

EM-163 Chemical Structure

EM-163 Chemical Structure

CAS No. : 1206480-93-4

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Description

EM-163 is a summative BB-Loop analog. EM-163 can alleviate inflammation and prevent death from toxic shock by targeting the TIR domain of MyD88. EM-163 can be used in the study of SEB poisoning (SEB: Staphylococcal enterotoxin B)[1].

In Vitro

EM-163 (50-100 μg/mL) can target the TIR domain, binding to the protein of the TIR domain and inhibit the interaction of the TIR-TIR domain [1].
EM-163 (10-500 μM; 30 min) inhibits the production of TNF-α, IFN-γ, IL-2 and IL-1b induced by SEB (200 ng/mL) in human mononuclear cells (MNS) [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

EM-163 (0.21-0.86 mg/mouse; i.p.; Single dose) can effectively inhibit the release of proinflammatory cytokines and delay or avoid death from toxic shock caused by Staphylococcal enterotoxin B (SEB) in BALB/c mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SEB-induced BALB/c mice model [1]
Dosage: 0.21 mg/mouse, 0.42 mg/mouse, 0.86 mg/mouse
Administration: Intraperitoneal injection (i.p.); Single dose. Before SEB treatment (0.5 μg/mouse, 5 μg/mouse; i.p.; single dose) and LPS treatment.
Result: Delayed mouse death at a dose of 0.21 mg/mouse, and protected mice from death at either dose of 0.42 mg/mouse or 0.86 mg/mouse.
Delayed mouse death even at high doses of SEB (5 μg).
Molecular Weight

849.88

Formula

C44H60IN5O4

CAS No.
SMILES

O=C(N1CCCC1)[C@H](C(C)C)N(CCCC2=CC=CC=C2)C(C3=C[N+](C)=C(C=C3)C(N(CCCC4=CC=CC=C4)[C@@H](C(C)C)C(N5CCCC5)=O)=O)=O.[I-]

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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EM-163
Cat. No.:
HY-163035
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