2. Protein Tyrosine Kinase/RTK
  3. c-Met/HGFR
  4. Emibetuzumab

Emibetuzumab  (Synonyms: LY2875358)

Cat. No.: HY-P99192 Purity: 95.00%
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Emibetuzumab (LY2875358) is a humanized bivalent MET antibody (IgG4 type). Emibetuzumab shows high neutralization and internalization activities, resulting in inhibition of both HGF-dependent and HGF-independent MET pathway activation and tumor growth. Emibetuzumab can be used in study of cancer.

For research use only. We do not sell to patients.

CAS No. : 1365287-97-3

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5 mg USD 540 In-stock
10 mg USD 860 In-stock
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Based on 1 publication(s) in Google Scholar

Emibetuzumab Related Antibodies

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Description

Emibetuzumab (LY2875358) is a humanized bivalent MET antibody (IgG4 type). Emibetuzumab shows high neutralization and internalization activities, resulting in inhibition of both HGF-dependent and HGF-independent MET pathway activation and tumor growth. Emibetuzumab can be used in study of cancer[1].

Isotype

Human IgG4 kappa
Recommend Isotype Controls
Species

Humanized
IC50 & Target

MET[1].
In Vitro

Emibetuzumab (LY2875358) (100 nmol/L; 6 days) inhibits HGF-stimulated proliferation of H596[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Emibetuzumab Related Antibodies

Cell Proliferation Assay[1]

Cell Line: H596 cells (HGF-stimulated)
Concentration: 100 nmol/L
Incubation Time: 6 days
Result: Suppressed cell proliferation.
In Vivo

Emibetuzumab (LY2875358) (10 mg/kg; i.v.; once a week for 5 weeks) inhibits in vivo growth of glioblastoma U87MG xenograft tumors in mice[1].
Emibetuzumab (10 or 20 mg/kg; i.v.; single) downregulates levels of MET and pMET in the tumors of mice[1].
Emibetuzumab (10 mg/kg; i.v.; once a week for 3, 5 or 6 weeks) exhibits antitumor effects on MET-amplified xenograft mouse tumor models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic nude mice (U87MG tumor xenograft model)[1].
Dosage: 10 mg/kg
Administration: Intravenous injection, once a week for 5 weeks.
Result: Demonstrated a significant inhibition of tumor growth.
Animal Model: Athymic nude mice (MKN45 xenograft tumor model)[1].
Dosage: 10 or 20 mg/kg
Administration: Intravenous injection, single.
Result: Reduced MET and pMET in the tumors by approximately 50% at both the 10 and 20 mg/kg doses by 72 hours post dose, and the reductions persisted to 14 days.
Animal Model: Athymic nude mice (MET-amplified xenograft mouse tumor models)[1].
Dosage: 10 mg/kg
Administration: Intravenous injection, once a week for 3, 5 or 6 weeks.
Result: Resulted in a marked reduction in tumor growth in the MKN45/SNU-5/EBC-1 gastric xenograft tumors.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Emibetuzumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
Purity & Documentation

Purity: 95.00%

SDS (251 KB)

COA (291 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Emibetuzumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Emibetuzumab1365287-97-3LY2875358LY 2875358LY-2875358c-Met/HGFRcancerH596tumorMKN45SNU-5EBC-1Inhibitorinhibitorinhibit

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