Enadoline  (Synonyms: CI-977)

Enadoline (CI-977) is a highly selective, brain-penetrating, and nonpeptide kappa-opioid receptor (KOR) agonist (K_i=1.25 nM). Antinociceptive effects^[1][2].

Enadoline (i.v.; dose of e 15 min before surgery; male Sprague-Dawley rats) dose-dependently (1-100 μg/kg) blocks the development of thermal hyperalgesia as well as static and dynamic allodynia for over 24 h with respective MEDs (minimum effective doses) of < or = 1, 10 and 10 μg/kg^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

396.52

C₂₄H₃₂N₂O₃

124378-77-4

O=C(CC1=C2C(OC=C2)=CC=C1)N([C@@H]3[C@](N4CCCC4)([H])C[C@]5(CCCO5)CC3)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Field MJ, et al. Enadoline, a selective kappa-opioid receptor agonist shows potent antihyperalgesic and antiallodynic actions in a rat model of surgical pain. Pain. 1999;80(1-2):383-389.  [Content Brief]

  [2]. Vanderah TW, Largent-Milnes T, Lai J, et al. Novel D-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral kappa-opioid receptors. Eur J Pharmacol. 2008;583(1):62-72.  [Content Brief]