2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. Enadoline

Enadoline (CI-977) is a highly selective, brain-penetrating, and nonpeptide kappa-opioid receptor (KOR) agonist (Ki=1.25 nM). Antinociceptive effects.

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Enadoline Chemical Structure

Enadoline Chemical Structure

CAS No. : 124378-77-4

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Enadoline Related Antibodies

Top Publications Citing Use of Products

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

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Description

Enadoline (CI-977) is a highly selective, brain-penetrating, and nonpeptide kappa-opioid receptor (KOR) agonist (Ki=1.25 nM). Antinociceptive effects[1][2].

In Vivo

Enadoline (i.v.; dose of e 15 min before surgery; male Sprague-Dawley rats) dose-dependently (1-100 μg/kg) blocks the development of thermal hyperalgesia as well as static and dynamic allodynia for over 24 h with respective MEDs (minimum effective doses) of < or = 1, 10 and 10 μg/kg[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

396.52

Formula

C24H32N2O3
CAS No.
SMILES

O=C(CC1=C2C(OC=C2)=CC=C1)N([C@@H]3[C@](N4CCCC4)([H])C[C@]5(CCCO5)CC3)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Enadoline Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Enadoline124378-77-4CI-977CI977CI 977Opioid ReceptorselectivebrainpenetratingnonpeptideantinociceptiveInhibitorinhibitorinhibit

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