2. PROTAC
  3. PROTAC Linkers
  4. endo-BCN-PEG4-PFP ester

endo-BCN-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. endo-BCN-PEG4-PFP ester is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

For research use only. We do not sell to patients.

endo-BCN-PEG4-PFP ester Chemical Structure

endo-BCN-PEG4-PFP ester Chemical Structure

CAS No. : 2904607-26-5

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5 mg USD 110 In-stock
10 mg USD 175 In-stock
25 mg USD 340 In-stock
50 mg USD 510 In-stock
100 mg USD 770 In-stock
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Based on 1 publication(s) in Google Scholar

endo-BCN-PEG4-PFP ester Related Antibodies

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Description

endo-BCN-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. endo-BCN-PEG4-PFP ester is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

endo-BCN-PEG4-PFP ester Related Antibodies
Molecular Weight

607.56

Formula

C28H34F5NO8
CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

O=C(OCC1C2CCC#CCCC12)NCCOCCOCCOCCOCCC(OC3=C(F)C(F)=C(F)C(F)=C3F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (411.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6459 mL 8.2296 mL 16.4593 mL
5 mM 0.3292 mL 1.6459 mL 3.2919 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6459 mL 8.2296 mL 16.4593 mL 41.1482 mL
5 mM 0.3292 mL 1.6459 mL 3.2919 mL 8.2296 mL
10 mM 0.1646 mL 0.8230 mL 1.6459 mL 4.1148 mL
15 mM 0.1097 mL 0.5486 mL 1.0973 mL 2.7432 mL
20 mM 0.0823 mL 0.4115 mL 0.8230 mL 2.0574 mL
25 mM 0.0658 mL 0.3292 mL 0.6584 mL 1.6459 mL
30 mM 0.0549 mL 0.2743 mL 0.5486 mL 1.3716 mL
40 mM 0.0411 mL 0.2057 mL 0.4115 mL 1.0287 mL
50 mM 0.0329 mL 0.1646 mL 0.3292 mL 0.8230 mL
60 mM 0.0274 mL 0.1372 mL 0.2743 mL 0.6858 mL
80 mM 0.0206 mL 0.1029 mL 0.2057 mL 0.5144 mL
100 mM 0.0165 mL 0.0823 mL 0.1646 mL 0.4115 mL
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endo-BCN-PEG4-PFP ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

endo-BCN-PEG4-PFP ester2904607-26-5PROTAC LinkersInhibitorinhibitorinhibit

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