2. Anti-infection
  3. Parasite
  4. Endochin

Endochin is an antimalarial agent. Endochin inhibits T.gondii with an IC50 of 0.003 nM. Endochin is also active against experimental toxoplasmosis.

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Endochin Chemical Structure

Endochin Chemical Structure

CAS No. : 354155-51-4

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Based on 1 publication(s) in Google Scholar

Endochin Related Antibodies

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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Description

Endochin is an antimalarial agent. Endochin inhibits T.gondii with an IC50 of 0.003 nM. Endochin is also active against experimental toxoplasmosis[1][2].

IC50 & Target

Plasmodium

 

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
> 10 μM
Compound: Endochin
Inhibition of human cytochrome bc1 complex derived from HEK293 cell mitochondria using 50 uM decylubiquinol as substrate
Inhibition of human cytochrome bc1 complex derived from HEK293 cell mitochondria using 50 uM decylubiquinol as substrate
[PMID: 24720377]
HepG2 IC50
> 10 μM
Compound: Endochin
Cytotoxicity against human HepG2 cells after 24 hrs incubation by Alamar Blue assay
Cytotoxicity against human HepG2 cells after 24 hrs incubation by Alamar Blue assay
[PMID: 24720377]
In Vitro

Endochin inhibits cytochrome c reduction by the T. gondii cytochrome bc1 complex, with an IC50 of 8.2 nM[1].
Endochin inhibits T. gondii with an IC50 of 0.003 nM[1].
Endochin (Compound 1) inhibits multidrug resistant W2 and TM90-C2B isolates of Plasmodium falciparum, with IC50s of 8.59 and 46.6 nM respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Endochin Related Antibodies
Molecular Weight

287.40

Formula

C18H25NO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C(CCCCCCC)=C(C)NC2=C1C=CC(OC)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 99.41%

SDS (251 KB)

COA (243 KB) HNMR (116 KB) LCMS (141 KB)

Handling Instructions (2659 KB)
References
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Endochin Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Endochin354155-51-4ParasiteAntimalarialT. gondiitoxoplasmosiscytochrome cTM90-C2BInhibitorinhibitorinhibit

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