2. Membrane Transporter/Ion Channel
  3. Na+/H+ Exchanger (NHE)
  4. Eniporide

Eniporide (EMD 96785) is a Na(+)/H(+) exchange (NHE) inhibitor. Eniporide specifically inhibits the NHE-1 isoform. Eniporide improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide regulates cardiac performance and high-energy phosphate content in clinically relevant pig models of CPB and cardiac arrest.

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Eniporide Chemical Structure

Eniporide Chemical Structure

CAS No. : 176644-21-6

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Eniporide Related Antibodies

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Description

Eniporide (EMD 96785) is a Na(+)/H(+) exchange (NHE) inhibitor. Eniporide specifically inhibits the NHE-1 isoform. Eniporide improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide regulates cardiac performance and high-energy phosphate content in clinically relevant pig models of CPB and cardiac arrest[1][2].

In Vitro

ENIPORIDE is a potent Na+/H+ exchange inhibitor.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Eniporide Related Antibodies
In Vivo

Eniporide (3 mg/kg; iv; systemic infusion before cardioplegia) improves cardiac performance and high energy phosphate content in healthy pig hearts subjected to ischemia/reperfusion induced by crystalloid cardioplegic arrest[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Clinically relevant pig models of cardiopulmonary bypass (CPB) and cardioplegia[1]
Dosage: 3 mg/kg
Administration: IV; systemic infusion before cardioplegia with added 2 μM Eniporide or not
Result: Had no effect on standard hemodynamics including vascular pressures and cardiac index nor for cardiac performance factors.
Reduced myocardial edema and improves heart function.
Molecular Weight

320.37

Formula

C14H16N4O3S
CAS No.
SMILES

CS(=O)(C1=C(N2C=CC=C2)C=C(C)C(C(NC(N)=N)=O)=C1)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Eniporide Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eniporide176644-21-6EMD-96785EMD96785EMD 96785Na+/H+ Exchanger (NHE)Sodium/hydrogen ExchangerSodium-hydrogen Exchangerbiochemical reagentbiological materialorganic compoundlife scienceInhibitorinhibitorinhibit

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