2. Protein Tyrosine Kinase/RTK Neuronal Signaling Autophagy Others
  3. ROS Kinase Trk Receptor Anaplastic lymphoma kinase (ALK) Autophagy Isotope-Labeled Compounds
  4. Entrectinib-d4

Entrectinib-d4  (Synonyms: NMS-E628-d4; RXDX-101-d4)

Cat. No.: HY-12678S
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Entrectinib-d4 (NMS-E628-d4; RXDX-101-d4) is the deuterium labeled Entrectinib (HY-12678). Entrectinib is an orally active, BBB-penetrated and centrally active inhibitor of TrkA/B/C, ROS1 and ALK, with IC50 values of 1, 3, 5, 12 and 7 nM, respectively. Entrectinib induces apoptosis and cycle arrest in cancer cells, has antitumor activity, and attenuates bleomycin-induced lung fibrosis in mice.

For research use only. We do not sell to patients.

Entrectinib-d<sub>4</sub> Chemical Structure

Entrectinib-d4 Chemical Structure

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Other Forms of Entrectinib-d4:

Entrectinib-d4 Related Antibodies

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TrkA TrkB TrkC Trk

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Description

Entrectinib-d4 (NMS-E628-d4; RXDX-101-d4) is the deuterium labeled Entrectinib (HY-12678). Entrectinib is an orally active, BBB-penetrated and centrally active inhibitor of TrkA/B/C, ROS1 and ALK, with IC50 values of 1, 3, 5, 12 and 7 nM, respectively. Entrectinib induces apoptosis and cycle arrest in cancer cells, has antitumor activity, and attenuates bleomycin-induced lung fibrosis in mice[1][2][3].

Molecular Weight

564.66

Formula

C31H30D4F2N6O2
Unlabeled CAS

1108743-60-7
SMILES

O=C(NC1=NNC2=C1C=C(CC3=CC(F)=CC(F)=C3)C=C2)C4=C(NC5C([2H])([2H])COCC5([2H])[2H])C=C(N6CCN(C)CC6)C=C4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Entrectinib-d4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Entrectinib-d4NMS-E628-d4 RXDX-101-d4ROS KinaseTrk ReceptorAnaplastic lymphoma kinase (ALK)AutophagyIsotope-Labeled CompoundsTropomyosin related kinase receptor Anaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246stable isotopesInhibitorinhibitorinhibit

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