2. Neuronal Signaling Protein Tyrosine Kinase/RTK Autophagy
  3. ROS Kinase Trk Receptor Anaplastic lymphoma kinase (ALK) Autophagy
  4. Entrectinib (Standard)

Entrectinib (Standard) 

Cat. No.: HY-12678R Purity: ≥98%
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Entrectinib (Standard) is the analytical standard of Entrectinib. This product is intended for research and analytical applications. Entrectinib (NMS-E628) is an orally active, BBB-penetrated and centrally active inhibitor of TrkA/B/C, ROS1 and ALK, with IC50 values of 1, 3, 5, 12 and 7 nM, respectively. Entrectinib induces apoptosis and cycle arrest in cancer cells, has antitumor activity, and attenuates bleomycin-induced lung fibrosis in mice.

For research use only. We do not sell to patients.

Entrectinib (Standard) Chemical Structure

Entrectinib (Standard) Chemical Structure

CAS No. : 1108743-60-7

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Description
Molecular Weight

560.64

Formula

C31H34F2N6O2
CAS No.
SMILES

O=C(NC1=NNC2=C1C=C(CC3=CC(F)=CC(F)=C3)C=C2)C4=C(NC5CCOCC5)C=C(N6CCN(C)CC6)C=C4
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Entrectinib (Standard) Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Entrectinib (Standard)1108743-60-7ROS KinaseTrk ReceptorAnaplastic lymphoma kinase (ALK)AutophagyTropomyosin related kinase receptor Anaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246KM12 cellscancerlung fibrosistumorfibroblasts cellsInhibitorinhibitorinhibit

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