EP3 antagonist 5

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EP3 antagonist 5 (Compound 22) is an EP3 receptor antagonist with an IC₅₀ value of 67 nM.

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EP3 antagonist 5 Chemical Structure

CAS No. : 499147-44-3

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Purity & Documentation
References
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Description

EP3 antagonist 5 (Compound 22) is an EP3 receptor antagonist with an IC₅₀ value of 67 nM^[1].

IC₅₀ & Target

IC50: 67 nM (EP3)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	67 nM Compound: 22	Antagonist activity at mouse EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase intracellular calcium level in presence of 1% BSA by fluorimetry Antagonist activity at mouse EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase intracellular calcium level in presence of 1% BSA by fluorimetry	[PMID: 20129791]

Molecular Weight

477.57

Formula

C₂₉H₃₂FNO₄

CAS No.

499147-44-3

SMILES

O=C(O)CCC1=CC=C(C=C1C(NC(C2=CC=C(C(F)=C2)C)CC(C)C)=O)COC3=CC=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Asada M, et al. 3-(2-Aminocarbonylphenyl) propanoic acid analogs as potent and selective EP3 receptor antagonists. Part 2: Optimization of the side chains to improve in vitro and in vivo potencies[J]. Bioorganic & medicinal chemistry, 2010, 18(4): 1641-1658. [Content Brief]

EP3 antagonist 5 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EP3 antagonist 5499147-44-3Prostaglandin ReceptorProstaglandin E2 (PGE2)Inhibitorinhibitorinhibit

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