Ep300/CREBBP-IN-3

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Ep300/CREBBP-IN-3 (Example 61) is a potent Ep300 and CREBBP inhibitor with IC₅₀s of 0.056 and 0.095 μM, respectively. Ep300/CREBBP-IN-3 can be used for the research of cancer.

For research use only. We do not sell to patients.

Ep300/CREBBP-IN-3 Chemical Structure

CAS No. : 2259641-47-7

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Description

Ep300/CREBBP-IN-3 (Example 61) is a potent Ep300 and CREBBP inhibitor with IC₅₀s of 0.056 and 0.095 μM, respectively. Ep300/CREBBP-IN-3 can be used for the research of cancer^[1].

IC₅₀ & Target^[1]

EP300

0.056 μM (IC₅₀)

CREBBP

0.095 μM (IC₅₀)

In Vitro

Ep300/CREBBP-IN-3 (Example 61) inhibits intracellular H3K27Ac activity with an IC₅₀ of 0.021 μM^[1].
Ep300/CREBBP-IN-3 (38 nM-10 mM; 3 days) inhibits LK2 and TE-8 cell growth with GI₅₀s of 148.858 and 215.717 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	LK2 and TE-8 cells
Concentration:	38 nM-10 mM
Incubation Time:	3 days
Result:	Inhibited LK2 and TE-8 cell growth with GI₅₀s of 148.858 and 215.717 μM, respectively.

Molecular Weight

531.50

Formula

C₂₆H₂₅F₄N₅O₃

CAS No.

2259641-47-7

SMILES

O=C([C@@H]1N(C(C2(C3=CC=C(C(C(F)(F)F)=O)C=C3)CCCCC2)=O)C[C@H](F)C1)NC4=CC=C(NN=C5)C5=N4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. NAITO Hiroyuki, et al. EP300 / CREBBP inhibitor. Patent JPWO2018235966A1.

Ep300/CREBBP-IN-3 Related Classifications

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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	×		=		×
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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ep300/CREBBP-IN-32259641-47-7Histone AcetyltransferaseHATsHATH3K27AcLK2TE-8Inhibitorinhibitorinhibit

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