1. Protein Tyrosine Kinase/RTK
  2. Ephrin Receptor
  3. EphA2 agonist 2

EphA2 agonist 2 (Lead compound) is a selective EphA2 agonist with antitumor activities. EphA2 agonist 2 can cross the BBB.

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EphA2 agonist 2 Chemical Structure

EphA2 agonist 2 Chemical Structure

CAS No. : 2169273-66-7

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Description

EphA2 agonist 2 (Lead compound) is a selective EphA2 agonist with antitumor activities. EphA2 agonist 2 can cross the BBB[1].

Cellular Effect
Cell Line Type Value Description References
U-251 IC50
2.1 μM
Compound: Table 4, Lead cpd
Antiproliferative activity against human U251 cells overexpressing EPHA2 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human U251 cells overexpressing EPHA2 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32828423]
U-251 IC50
5.2 μM
Compound: Table 4, Lead cpd
Antiproliferative activity against wild-type human U251 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against wild-type human U251 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32828423]
In Vitro

EphA2 agonist 2 (Lead compound) shows antiproliferation activity with IC50 values of 2.1 ± 1.05 μM and 5.2 ± 2.56 μM against U251 EphA2 overexpressed and U251 wild type cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

772.94

Formula

C40H56N10O6

CAS No.
SMILES

O=C(N1CCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)CCCCCCCCCCC(N4CCN(C5=NC(N)=C6C=C(OC)C(OC)=CC6=N5)CC4)=O

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
EphA2 agonist 2
Cat. No.:
HY-146141
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