2. Apoptosis
  3. TNF Receptor
  4. Epobis

Epobis, a dendrimeric peptide, is a recombinant form of erythropoietin. Epobis is a potent erythropoietin receptor agonist. Epobis promotes neuritogenesis in primary motoneurons. Epobis decrease TNF release and crosses the blood-brain barrier. Epobis has anti-inflammatory and memory enhancing properties.

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Epobis Chemical Structure

Epobis Chemical Structure

CAS No. : 915091-83-7

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Based on 1 publication(s) in Google Scholar

Epobis Related Antibodies

Top Publications Citing Use of Products

View All TNF Receptor Isoform Specific Products:

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Epobis, a dendrimeric peptide, is a recombinant form of erythropoietin. Epobis is a potent erythropoietin receptor agonist. Epobis promotes neuritogenesis in primary motoneurons. Epobis decrease TNF release and crosses the blood-brain barrier. Epobis has anti-inflammatory and memory enhancing properties[1].

In Vitro

Epobis (0-8.82 μM) stimulates neurite outgrowth from motor neurons in a dose-dependent manner with maximal stimulation at 0.33 μM[1].
Epobis (0-8.82 μM; 24 h) reduces release of TNF and improves the survival of the L929 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Epobis Related Antibodies

Cell Viability Assay[1]

Cell Line: L929 cells
Concentration: 0-8.82 μM
Incubation Time: 24 hours
Result: Had a significantly higher viability of 64% in a concentration of 8.4 μM, whereas the highest viability (68%) in a concentration of 2.7 μM.
In Vivo

Epobis (10 mg/kg; i.h.; Wistar rats) can cross the blood-brain barrier (BBB)[1].
Epobis (10 mg/kg; i.h.) has an anti-inflammatory effect in mice of multiple sclerosis model[1].
Epobis (10 mg/kg; i.h.; old (>18 month) rats and in rats experiencing early stage AD) improves social memory[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (200 g)[1]
Dosage: 10 mg/kg
Administration: Subcutaneous injection; once
Result: Had detectable already 15 min after administration and remained detectable in the blood for at least 24 h.
Animal Model: Wistar rats with multiple sclerosis model (200 g)[1]
Dosage: 10 mg/kg
Administration: Subcutaneous injection; once
Result: Had no significant effects on the weight changes or the survival of experimental autoimmune encephalomyelitis (EAE) animals.
Animal Model: Old (>18 month) rats and in rats experiencing early stage AD[1]
Dosage: 10 mg/kg
Administration: Subcutaneous injection; once
Result: Had significantly lower than that of vehicle-treated animals.
Molecular Weight

2195.44

Formula

C100H151N27O29
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

NENITVPDTKVNFYAWKR
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (22.77 mM)

DMSO : 4 mg/mL (1.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4555 mL 2.2774 mL 4.5549 mL
5 mM 0.0911 mL 0.4555 mL 0.9110 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 0.4555 mL 2.2774 mL 4.5549 mL 11.3872 mL
H2O 5 mM 0.0911 mL 0.4555 mL 0.9110 mL 2.2774 mL
10 mM 0.0455 mL 0.2277 mL 0.4555 mL 1.1387 mL
15 mM 0.0304 mL 0.1518 mL 0.3037 mL 0.7591 mL
20 mM 0.0228 mL 0.1139 mL 0.2277 mL 0.5694 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Epobis Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Epobis915091-83-7TNF ReceptorTumor Necrosis Factor ReceptorTNFRdendrimeric peptideerythropoietinneuritogenesisanti-inflammatoryblood-brain barriermemory enhancingInhibitorinhibitorinhibit

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