Epoprostenol sodium (Synonyms: Prostaglandin I2 sodium salt; Prostacyclin sodium salt; Flolan)

Name: Epoprostenol sodium
Brand: MedChemExpress
SKU: HY-A0126A
Rating: 4.5 (1 reviews)

Cat. No.: HY-A0126A Purity: 98.38%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Epoprostenol sodium (Prostaglandin I2) sodium salt, the synthetic form of the natural prostaglandin derivative prostacyclin (prostaglandin I2), is registered worldwide for the treatment of Pulmonary arterial hypertension (PAH). Epoprostenol sodium is used in pulmonary hypertension and transplantation as a potent inhibitor of platelet aggregation.

For research use only. We do not sell to patients.

Epoprostenol sodium Chemical Structure

CAS No. : 61849-14-7

Size	Price	Stock	Quantity
1 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 320	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 540	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1100	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1750	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2800	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Epoprostenol sodium:

Epoprostenol Get quote
Epoprostenol sodium (Standard) Get quote

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Description

IC₅₀ & Target

Human Endogenous Metabolite

In Vitro

Epoprostenol (1.0 ng/mL; 24 h) sodium induces apoptosis in PAH-PASMCs by upregulating the expression of IP receptor and Fas ligand (FasL)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

374.45

Formula

C₂₀H₃₁NaO₅

CAS No.

61849-14-7

Appearance

Solid

Color

White to yellow

SMILES

CCCCC[C@H](O)/C=C/[C@@H]1[C@H]([C@@]2([H])C[C@H]1O)C/C(O2)=C/CCCC(O[Na])=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility

In Vitro:

H₂O : 25 mg/mL (66.76 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6706 mL	13.3529 mL	26.7058 mL
5 mM	0.5341 mL	2.6706 mL	5.3412 mL
10 mM	0.2671 mL	1.3353 mL	2.6706 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.38%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (253 KB) HNMR (227 KB) RP-HPLC (258 KB) MS (69 KB)

Handling Instructions (2659 KB)

References

[1]. Provencher S, et al.Quality of life, safety and efficacy profile of thermostable flolan in pulmonary arterialhypertension. PLoS One. 2015 Mar 20;10(3):e0120657. [Content Brief]

[2]. Lambert O, et al. Stability and microbiological properties of a new formulation of epoprostenol sodium when reconstituted and diluted[J]. Drug Design, Development and Therapy, 2012: 61-70. [Content Brief]

[3]. Akagi S, et al. Prostaglandin I2 induces apoptosis via upregulation of Fas ligand in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension[J]. International journal of cardiology, 2013, 165(3): 499-505. [Content Brief]

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.6706 mL	13.3529 mL	26.7058 mL	66.7646 mL
	5 mM	0.5341 mL	2.6706 mL	5.3412 mL	13.3529 mL
	10 mM	0.2671 mL	1.3353 mL	2.6706 mL	6.6765 mL
	15 mM	0.1780 mL	0.8902 mL	1.7804 mL	4.4510 mL
	20 mM	0.1335 mL	0.6676 mL	1.3353 mL	3.3382 mL
	25 mM	0.1068 mL	0.5341 mL	1.0682 mL	2.6706 mL
	30 mM	0.0890 mL	0.4451 mL	0.8902 mL	2.2255 mL
	40 mM	0.0668 mL	0.3338 mL	0.6676 mL	1.6691 mL
	50 mM	0.0534 mL	0.2671 mL	0.5341 mL	1.3353 mL
	60 mM	0.0445 mL	0.2225 mL	0.4451 mL	1.1127 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Epoprostenol sodium Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Epoprostenol61849-14-7Prostaglandin I2Prostacyclin FlolanProstaglandin I 2Prostaglandin I-2Endogenous MetaboliteApoptosisInhibitorinhibitorinhibit

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Epoprostenol sodium (Synonyms: Prostaglandin I2 sodium salt; Prostacyclin sodium salt; Flolan)

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Other Forms of Epoprostenol sodium:

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Epoprostenol sodium Related Antibodies

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Complete Stock Solution Preparation Table

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