ER-076349 

ER-076349 is an inhibitor of tubulin polymerization, induces G2-M cell cycle arrest, and disrupts mitotic spindles. ER-076349 inhibits cancer cell growth, and inhibits tumor growth in several human tumor xenografts. ER-076349 is an analog of Halichondrin B^[1].

ER-076349 inhibits human cancer cell growth with IC₅₀s of 0.59 nM (MDA-MB-435), 2.4 nM (COLO 205), 7.3 nM (DLD-1), 3.6 nM (DU 145), 1.8 nM (LNCaP), 3.2 nM (LOX ), 2.6 nM (HL-60), 4.0 nM (U937) respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

730.88

C₄₀H₅₈O₁₂

253128-15-3

Solid

White to off-white

C=C1C[C@@](CC[C@@]2(C[C@@]3([H])O4)O[C@]([C@](O[C@](C5)([H])CC6)([H])[C@@]6([H])O7)([H])[C@@]4([H])[C@]7([H])[C@@]3([H])O2)([H])O[C@@]1([H])CC[C@](C[C@@H](C)C8=C)([H])O[C@]8([H])C[C@@](O[C@H](C[C@H](O)CO)[C@@H]9OC)([H])[C@]9([H])CC5=O

Shipping with dry ice.

-80°C, protect from light, stored under nitrogen

• [1]. Towle MJ, et al. In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B. Cancer Res. 2001 Feb 1;61(3):1013-21.  [Content Brief]