2. Protein Tyrosine Kinase/RTK
  3. TAM Receptor
  4. ER-851

ER-851 is a selective AXL inhibitor with oral activity with IC50 of 100 nM. ER-851 has antitumor activity.

For research use only. We do not sell to patients.

ER-851 Chemical Structure

ER-851 Chemical Structure

CAS No. : 2685738-33-2

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ER-851 Related Antibodies

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Axl Mer Tyro3

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Description

ER-851 is a selective AXL inhibitor with oral activity with IC50 of 100 nM. ER-851 has antitumor activity[1].

In Vivo

ER-851 (1-100 mg/kg, gavage once a day) inhibits tumor growth in mouse tumor models with xenografted HeLa and HCC1806 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

668.76

Formula

C36H41FN8O4
CAS No.
SMILES

O=C(C(C(N1C2=NC=C(C)C=C2)=O)=CN(C3CCCC3)C1=O)NC(C=C4F)=CC=C4OC5=NC=NC6=C5CCN(CC7CCN(C)CC7)C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ER-851 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ER-8512685738-33-2ER851ER 851TAM ReceptorTyro3AxlMerAXLInhibitorantitumorinhibitorinhibit

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HY-164382
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